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Cell division

life science Maturity 11-13 Next article →

Cell division is the fundamental biological process by which a parent cell divides into two or more daughter cells. This mechanism is essential for life, serving as the primary way organisms grow, repair damaged tissues, and reproduce. In simple unicellular organisms like the amoeba, a single cell division results in the creation of an entirely new organism. In complex multicellular organisms, cell division allows a single fertilized egg, known as a zygote, to develop into a mature adult.

Cell Cycle 2
Cell Cycle 2

The main objective of this process is to maintain the integrity of the genome, which is the complete set of genetic instructions stored in chromosomes.

In eukaryotic cells, the process is part of a larger, highly regulated sequence called the cell cycle. Before division can begin, a cell must undergo interphase. This stage is divided into three distinct phases: G1, S, and G2. During the G1 phase, the cell grows and performs its specialized functions. Next, during the S phase, or synthesis phase, the cell replicates its DNA so that each new cell will have a complete set of instructions. Finally, in the G2 phase, the cell undergoes final growth and synthesizes the spindle apparatus.

Animal cell cycle-en
Animal cell cycle-en

To ensure accuracy, the cell uses checkpoints to detect DNA damage or improper cell size. These checkpoints are controlled by cyclin and cyclin-dependent kinases, which act as signals to push the cell forward or halt its progress.

Eukaryotes utilize two main types of division: mitosis and meiosis. Mitosis is an equational division used for vegetative growth and tissue repair. It produces two daughter cells that are genetically identical to the parent cell. Meiosis, however, is a reductional division used for sexual reproduction. It involves two rounds of division that result in four haploid daughter cells, known as gametes. These gametes contain only one copy of each chromosome type, which is necessary so that when they fuse, the resulting offspring has the correct number of chromosomes.

Kinetochore
Kinetochore

In some organisms, such as plants, meiosis produces spores rather than gametes, a process called sporic meiosis.

Mitosis itself follows a specific sequence of stages within the M phase. It begins with prophase, where the nuclear envelope breaks down and chromatin condenses into visible chromosomes. During prometaphase, the spindle apparatus attaches to the kinetochores, which are protein structures on the sister chromatids. In metaphase, the chromosomes align along the metaphase plate, an imaginary line in the center of the cell. This alignment is achieved by microtubule organizing centers pushing and pulling on the centromeres.

Time-lapse video of dividing cells
Time-lapse video of dividing cells

This careful positioning ensures that each new cell receives the correct genetic material.

Anaphase is a rapid and critical stage that follows metaphase. Once the chromosomes are correctly attached, the anaphase-promoting complex triggers the degradation of specific proteins, such as securin. The breakdown of securin releases an enzyme called separase, which cleaves the cohesin rings holding the sister chromatids together. As a result, the spindle fibers pull the separated chromatids toward opposite poles of the cell. This is followed by telophase, where the chromosomes reach the poles and the cell prepares to split. Finally, cytokinesis divides the cytoplasm, organelles, and cell membrane into two distinct cells.

Prokaryotes, such as bacteria and archaea, follow a different path known as binary fission. This is a simpler form of vegetative division where the genetic material is segregated equally into two new cells. In bacteria, a protein complex called the divisome is responsible for dividing the cell and remodeling the peptidoglycan cell wall. A specific tubulin-like protein called FtsZ plays a vital role by forming a contractile ring to help the cell divide.

Divisome
Divisome

Some prokaryotes may also use alternative methods like budding to create new cells.

The scale and importance of cell division are immense. In a single human lifetime, the body undergoes approximately 10 quadrillion cell divisions. This constant cycle of division is what allows for the continual construction and repair of the human body. From the microscopic movements of a single bacterium to the complex development of a human being, cell division is the engine that drives the continuity of life across all biological kingdoms.

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🖼️ Images & Media (7)
File:Three cell growth types.svg
Three cell growth types.svg
File:Cell Cycle 2.svg
Cell Cycle 2.svg
File:Divisome.jpg
Divisome.jpg
File:Animal cell cycle-en.svg
Animal cell cycle-en.svg
File:Kinetochore.jpg
Kinetochore.jpg
File:Time-lapse video of dividing cells.gif
Time-lapse video of dividing cells.gif
File:1943 Device for micro-cinematography- under the direction of Kurt Michel, the first film on cell division is produced in a Zeiss laboratory with the aid of a phase-contrast microscope (6892933110).jpg
1943 Device for micro-cinematography-...
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