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Mitosis

life science Maturity 7-9 Next article →

Mitosis is a fundamental process within the eukaryotic cell cycle. It is the mechanism by which a single parent cell divides to produce two genetically identical daughter cells. This process is known as equational division because it maintains the exact same number of chromosomes in each new cell. By ensuring genetic stability, mitosis allows organisms to grow, repair tissues, and replace worn-out cells. Without this precise duplication and separation, life could not maintain the complex instructions required for biological function.

Animal cell cycle-en
Animal cell cycle-en

Before mitosis begins, the cell must undergo a long preparation period called interphase. Interphase is divided into three distinct subphases: G1 (first gap), S (synthesis), and G2 (second gap). During the S phase, the cell performs DNA replication, creating an exact copy of its entire genome. These copies consist of two identical sister chromatids held together at a point called the centromere. The cell also grows by producing proteins and various organelles during these stages. Highly regulated proteins, such as cyclins and cyclin-dependent kinases, act as checkpoints to ensure the DNA is undamaged before the cell proceeds to the M phase.

CONDENSING CHROMOSOMES 2
CONDENSING CHROMOSOMES 2

The mitotic phase, or M phase, follows a strict sequence of stages to ensure accuracy. In prophase, the loosely packed chromatin condenses into thick, visible chromosomes. The nucleolus disappears, and gene transcription stops. In animal cells, the centrosomes move to opposite sides of the cell to organize microtubules into a spindle apparatus. In the subsequent stage, prometaphase, the nuclear envelope disintegrates into small vesicles. This allows the microtubules to reach the chromosomes and attach to their centromeres.

Prophase diagram
Prophase diagram

As the process continues, the cell enters metaphase and anaphase to organize the genetic material. During metaphase, the spindle fibers pull the chromosomes until they align perfectly in the center of the cell. This alignment is crucial for the next step. In anaphase, the connection between sister chromatids is broken, and they are pulled toward opposite poles of the cell. These separated chromatids are now referred to as daughter chromosomes. As the cell elongates, these chromosomes reach their maximum condensation at the end of this stage.

Metaphase during Mitosis
Metaphase during Mitosis
Anaphase during Mitosis
Anaphase during Mitosis

The final stages of nuclear and cellular division are telophase and cytokinesis. During telophase, a new nuclear envelope forms around each of the two sets of daughter chromosomes. The chromosomes also begin to decondense, returning to their looser chromatin state. Following this, cytokinesis divides the remaining cytoplasm, organelles, and cell membrane. In animal cells, the cell membrane pinches inward to split the cell into two. In contrast, plant cells must construct a new cell plate to divide the cell.

Telophase during Mitosis
Telophase during Mitosis
Cytokinesis illustration
Cytokinesis illustration

Scientists have spent centuries uncovering the mechanics of cell division. In 1835, the German botanist Hugo von Mohl described cell multiplication in the green algae *Cladophora glomerata*. Later, in 1875, Wacław Mayzel provided the first descriptions of mitosis in animal cells, specifically observing frog, rabbit, and cat cornea cells. The specific term "mitosis" was coined by Walther Flemming in 1882, derived from the Greek word *mitos*, meaning "warp thread." This name reflects the thread-like appearance of the chromosomes during the process.

Stages of early mitosis in a vertebrate cell with micrographs of chromatids
Stages of early mitosis in a vertebrate cell with micrographs of chromatids

While mitosis is highly efficient, errors can occur during the process. If a cell undergoes tripolar or multipolar mitosis, it may produce three or more daughter cells instead of two. Such errors can lead to non-viable embryos that fail to implant. Other mistakes can trigger mitotic catastrophe, apoptosis (programmed cell death), or genetic mutations. These mutations are a known cause of certain types of cancers. Furthermore, mitosis varies by organism; for example, fungal cells often undergo "closed mitosis," where the nucleus remains intact, unlike the "open mitosis" seen in most animal cells.

Atypical mitosis
Atypical mitosis
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🖼️ Images & Media (16)
File:Animal cell cycle-en.svg
Animal cell cycle-en.svg
Mitosis drosophila larva.ogv
File:Stages of early mitosis in a vertebrate cell with micrographs of chromatids.svg
Stages of early mitosis in a vertebrate...
File:CONDENSING CHROMOSOMES 2.jpg
CONDENSING CHROMOSOMES 2.jpg
File:Prophase diagram.svg
Prophase diagram.svg
File:Mitosis-fluorescent.jpg
Mitosis-fluorescent.jpg
File:Metaphase during Mitosis.svg
Metaphase during Mitosis.svg
File:Anaphase during Mitosis.svg
Anaphase during Mitosis.svg
File:Telophase during Mitosis.svg
Telophase during Mitosis.svg
File:Cytokinesis illustration.svg
Cytokinesis illustration.svg
File:Unk.cilliate.jpg
Unk.cilliate.jpg
File:Atypical mitosis.jpg
Atypical mitosis.jpg

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