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Centriole

life science Maturity 11-13 Next article →

A centriole is a cylindrical organelle found within most eukaryotic cells. It is primarily composed of a protein called tubulin. These tiny structures are essential for organizing the internal layout of a cell. They play a critical role in determining the position of the nucleus. Centrioles also help manage the spatial arrangement of the cell's components.

Blausen 0214 Centrioles
Blausen 0214 Centrioles

Centrioles usually exist in pairs within a larger structure called a centrosome. This centrosome is surrounded by a dense, highly ordered mass of material known as the pericentriolar material, or PCM. The two centrioles in a centrosome are typically attached to one another at a right angle, which is called an orthogonal arrangement. This organized structure helps the cell manage its internal environment and prepare for division.

Most centrioles follow a specific structural pattern. They are built from nine sets of microtubule triplets arranged in a cylinder. However, there are notable deviations from this standard design in nature. For example, the fruit fly *Drosophila melanogaster* has nine microtubule doublets. The tiny worm *Caenorhabditis elegans* uses nine singlets in its sperm cells and early embryos.

Centriole-en
Centriole-en

Centrioles undergo a specific process of self-replication during the cell cycle. Before DNA replication begins, a cell contains one older mother centriole and one younger daughter centriole. During cell division, a new centriole grows at the proximal end of both existing centrioles. After this duplication, the two new pairs remain attached orthogonally until mitosis occurs. At that point, an enzyme called separase helps the mother and daughter centrioles separate.

Centriole-en
Centriole-en

Our understanding of these structures grew through many scientific discoveries. Walther Flemming and Edouard Van Beneden jointly discovered the centrosome in 1875 and 1876. In 1883, Van Beneden observed that centrosomes consisted of two orthogonal centrioles. Theodor Boveri later introduced the term "centrosome" in 1888 and the term "centriole" in 1895. Additionally, Theodor Wilhelm Engelmann named the basal body in 1880. Finally, Étienne de Harven and Joseph G. Gall independently worked out the pattern of centriole duplication around 1950.

The functions of centrioles are vital for reproduction and movement. During interphase, they are responsible for producing cilia, which are hair-like structures on cells. In sperm cells, centrioles are necessary to form the flagellum, or the tail that allows for movement. The sperm also provides the centriole required to create the centrosome and microtubule system in a new zygote.

Spindle centriole - embryonic brain mouse - TEM
Spindle centriole - embryonic brain mouse - TEM

Errors in centriole function can lead to serious biological consequences. If cells cannot use centrioles to build functional flagella or cilia, it can cause genetic diseases. Specifically, the inability of centrioles to migrate properly before ciliary assembly is linked to Meckel–Gruber syndrome. While some experiments show cells can survive without centrioles via a process called *de novo* synthesis, mutant flies lacking them die shortly after birth because they lack cilia.

Spindle centriole - embryonic brain mouse - TEM
Spindle centriole - embryonic brain mouse - TEM

Centrioles are not universal to all life. They are absent in conifers, flowering plants, and most fungi. They only appear in the male gametes of specific groups like bryophytes and certain seedless vascular plants. This suggests that the last common ancestor of all eukaryotes, known as LECA, was a ciliated cell with centrioles. This evolutionary history shows how these small organelles have shaped the diversity of life on Earth.

Blausen 0214 Centrioles
Blausen 0214 Centrioles
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File:Blausen 0214 Centrioles.png
Blausen 0214 Centrioles.png
File:Centriole-en.svg
Centriole-en.svg
File:Spindle centriole - embryonic brain mouse - TEM.jpg
Spindle centriole - embryonic brain mouse...
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