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Organelle

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An organelle is a specialized subunit found within a biological cell. Each organelle performs a specific function to help the cell operate. The term comes from the word "organ," which refers to a functional unit in a body. The suffix "-elle" is a diminutive, meaning "little organ."

Typical human cell
Typical human cell

Organelles are essential because they allow a cell to organize different tasks into separate areas. This organization helps life function efficiently at a microscopic level.

Organelles are categorized by how they are structured. Many are membrane-bound organelles. These are enclosed within their own lipid bilayers, which are thin layers of fats. Other structures are non-membrane-bound organelles, also called membrane-less organelles (MLOs). These are large assemblies of macromolecules, such as proteins, that carry out specialized tasks. Some MLOs are referred to as proteinaceous organelles because proteins form their main structure.

Carboxysomes EM
Carboxysomes EM

The formation of these membrane-less structures is sometimes compared to liquid-liquid phase separation.

In eukaryotic cells, organelles form complex systems. The endomembrane system includes parts like the nuclear envelope, the endoplasmic reticulum, and the Golgi apparatus. The nucleus is a double-membrane compartment that maintains DNA and controls cell activities. The endoplasmic reticulum helps with the translation and folding of new proteins. The Golgi apparatus then sorts, packages, and modifies these proteins.

Typical human cell
Typical human cell

Other major organelles include mitochondria, which produce energy from glucose, and vacuoles, which handle storage and transportation.

Plants, algae, and some protists possess additional types of organelles called plastids. A common example is the chloroplast, which is a double-membrane compartment. Chloroplasts perform photosynthesis by trapping energy from sunlight. Mitochondria and plastids are unique because they are considered endosymbiotic. This means they were likely engulfed by an ancestral cell long ago.

Typical human cell
Typical human cell

The number of these organelles can change depending on what the specific cell needs to do.

Historically, the study of these structures has evolved significantly. In the 1830s, Félix Dujardin refuted a theory by Ehrenberg. Ehrenberg believed microorganisms had the same organs as multicellular animals, just smaller. In 1884, German zoologist Karl August Möbius is credited with first using the term "organella." He used this diminutive of "organ" to explain that these were parts of a single cell. This helped scientists distinguish between cellular structures and the organs of complex animals.

While eukaryotes are highly complex, prokaryotes also have specialized structures. For a long time, it was thought that prokaryotes lacked internal organization. However, research shows that some bacteria contain protein-shelled microcompartments called carboxysomes. These are very small, measuring only 100 to 200 nanometers in diameter.

Carboxysomes EM
Carboxysomes EM

Other bacteria, such as those in the phylum Planctomycetota, have internal membranes. Some even have anammoxosomes for specific chemical processes.

Brocadia anammoxidans
Brocadia anammoxidans

Scientists identify and study these structures using various tools. Microscopy allows researchers to see larger organelles, like the nucleus, under a light microscope. For smaller details, more advanced methods are required. Cell fractionation is a process used to purify specific organelles for study. This allows scientists to separate the different parts of a cell to examine them individually. Understanding these components connects us to the broader study of how all living systems are organized.

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Typical human cell.tif
File:Carboxysomes EM.jpg
Carboxysomes EM.jpg
File:Brocadia anammoxidans.jpg
Brocadia anammoxidans.jpg
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