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Sleep

life science Maturity 11-13 Vital Level 3 Next article →

Sleep is a physiological state characterized by reduced mental and physical activity. During this state, consciousness is altered and certain sensory activities are inhibited. While sleep involves a marked decrease in muscle activity, the brain remains highly active. This makes sleep more reactive than a coma or other disorders of consciousness.

WLA metmuseum Bronze statue of Eros sleeping 7
WLA metmuseum Bronze statue of Eros sleeping 7

Sleep is a highly conserved behavior in animal evolution. It likely originated hundreds of millions of years ago. One core purpose may be to allow the brain to cleanse itself of waste products, such as amyloid. This process is vital for maintaining mood, memory, and cognitive function.

Effects of sleep deprivation
Effects of sleep deprivation

The brain undergoes significant changes during sleep. It uses much less energy than it does while awake. During non-REM sleep, the brain's energy demands drop significantly. Specifically, the cerebral metabolic rate of glucose decreases by 44%. The cerebral metabolic rate of oxygen also drops by 25%. This reduction is important because the brain is responsible for 20% of the body's total energy use. In areas of reduced activity, the brain restores its supply of adenosine triphosphate (ATP). ATP is the molecule used for the short-term storage and transport of energy.

Biological clock human
Biological clock human

Sleep occurs in repeating cycles that last approximately 90 minutes on average. A single night of good sleep typically includes four to six of these cycles. The cycle follows a specific order: N1, then N2, then N3, then back to N2, and finally REM.

Biological clock human
Biological clock human

Non-REM (NREM) sleep is the first part of this process. NREM is divided into three stages by the American Academy of Sleep Medicine (AASM). Stage N1 is the transition into sleep. Stage N2 follows N1. Stage N3 is known as slow-wave sleep or delta sleep. This is the deepest stage of sleep. During N3, the body temperature and heart rate fall. REM sleep, or rapid eye movement sleep, is also called paradoxical sleep. This stage is the primary time for dreaming. In REM, the brain shows fast, desynchronized waves and the body experiences a loss of muscle tone.

Scientists measure sleep using various electrical tools to track brain and body activity. An electroencephalography (EEG) measures brain waves. The amplitude and frequency of these waves indicate different sleep stages. Alpha waves appear during a resting state when a person is still conscious. Beta waves occur when a person is fully alert and concentrating. Theta waves appear during the transition into Stage 1 and Stage 2 sleep. Delta waves are seen during the deepest stages, N3 and N4.

Biological clock human
Biological clock human

Other tools include electrooculography (EOG) for eye movements and electromyography (EMG) for muscle activity. When these are collected together, it is called polysomnography. Researchers also use electrocardiography (EKG) for the heart and actigraphy for movement.

Pillow Height in Side-Lying Position
Pillow Height in Side-Lying Position

Timing is controlled by a complex system known as the circadian clock, or Process C. This internal clock uses environmental signals to create a day-night rhythm. The suprachiasmatic nucleus (SCN) is the most important center for this process. The SCN has a direct neural connection to the pineal gland. At night, the SCN triggers the pineal gland to release melatonin. Melatonin is the hormone needed to regulate the sleep cycle.

Biological clock human
Biological clock human

Other hormones also play roles. Cortisol levels rise throughout the night and peak during awakening. Prolactin secretion also increases, peaking in the middle of the night. During slow-wave sleep, the body secretes bursts of growth hormone. This helps restore the immune, nervous, skeletal, and muscular systems.

Modern technology can disrupt these natural rhythms. Artificial light, especially the blue light from smartphones and televisions, is a major factor. Blue light is a form of light typically associated with daytime. Exposure to it at night can suppress melatonin secretion. This can lead to circadian rhythm sleep disorders. Many humans now experience chronic circadian desynchronization. This happens due to night shifts, long-distance travel, or universal indoor lighting.

2023 CDC recommendations for amount of sleep needed, by age
2023 CDC recommendations for amount of sleep needed, by age

Even if a person has sleep debt, they may find it difficult to sleep during certain parts of their cycle. Conversely, they may struggle to wake up during the trough of the cycle.

Sleep disorders can affect many different parts of life. Dyssomnias include conditions like insomnia, hypersomnia, narcolepsy, and sleep apnea. Parasomnias include sleepwalking and rapid eye movement sleep behavior disorder. Other issues include bruxism, which is teeth grinding. Understanding these mechanisms is essential for medical research. The diverse purposes and mechanisms of sleep remain a subject of substantial ongoing research.

Effects of sleep deprivation
Effects of sleep deprivation
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🖼️ Images & Media (11)
File:1900 The Awakening.jpg
1900 The Awakening.jpg
File:Pillow Height in Side-Lying Position.png
Pillow Height in Side-Lying Position.png
File:Biological clock human.svg
Biological clock human.svg
File:Hombre echando una siesta en San Cristóbal, Cusco, Perú, 2015-07-31, DD 49.JPG
Hombre echando una siesta en San...
File:2023 CDC recommendations for amount of sleep needed, by age.svg
2023 CDC recommendations for amount of...
File:Effects of sleep deprivation.svg
Effects of sleep deprivation.svg
File:WLA metmuseum Bronze statue of Eros sleeping 7.jpg
WLA metmuseum Bronze statue of Eros sleeping 7.jpg
File:"Plenty of sleep keeps him on the job" - NARA - 514792.jpg
"Plenty of sleep keeps him on the job" -...
File:Glimpse of a dream (9391068364).jpg
Glimpse of a dream (9391068364).jpg
File:Pieter Bruegel d. Ä. 037.jpg
Pieter Bruegel d. Ä. 037.jpg
File:Seven sleepers (Menologion of Basil II).jpg
Seven sleepers (Menologion of Basil II).jpg
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