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Rubella

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Rubella is a viral infection that humans can catch.

Rubella virus TEM B82-0203 lores
Rubella virus TEM B82-0203 lores

It is often called German measles or three-day measles. For many people, the sickness is very mild. In fact, half of the people who catch it do not even know they are infected. The name rubella comes from a Latin word meaning "little red." This refers to the pink or light red rash that many people develop. While it is often a minor illness, it is very important to understand. This is because the virus can cause severe harm to unborn babies.

The disease is caused by the rubella virus. This virus belongs to the genus Rubivirus and the family Matonaviridae.

Rubella virus TEM B82-0203 lores
Rubella virus TEM B82-0203 lores

It is an enveloped virus with a single-stranded RNA genome. The virus spreads through the respiratory route. This means it travels through the air when an infected person coughs. Once inside, the virus replicates in the nasopharynx and the lymph nodes. It can be found in the blood five to seven days after infection. From the blood, it spreads throughout the entire body. A person is contagious for about one week before the rash appears. They remain contagious for about one week after the rash shows up.

Symptoms of rubella can vary depending on the person's age. In children, the illness usually lasts about two days. The main sign is a rash that starts on the face. This rash then spreads to the trunk and the limbs. The rash is typically pink or light red and may be itchy. It usually fades after three days without leaving scars. Other symptoms in children include a low fever and swollen glands. In older children and adults, the symptoms can be more diverse. Adults may experience aching joints, especially young females. They might also have a sore throat, headache, or a fever. Some people develop Forchheimer spots, which are small red bumps on the soft palate. These spots appear in about 20% of cases.

One of the most serious parts of rubella involves pregnancy. The virus has teratogenic properties, which means it can interfere with a baby's development. If a woman is infected, the virus can cross the placenta. This can lead to congenital rubella syndrome, or CRS.

Cataracts due to Congenital Rubella Syndrome (CRS) PHIL 4284 lores
Cataracts due to Congenital Rubella Syndrome (CRS) PHIL 4284 lores

The risk of major defects is highest during the first trimester. Between 80% and 90% of mothers infected in this period face a miscarriage or a stillborn baby. If the baby survives, they may be born with CRS. This syndrome can cause deafness, blindness from cataracts, or heart disorders.

Cataracts due to Congenital Rubella Syndrome (CRS) PHIL 4284 lores
Cataracts due to Congenital Rubella Syndrome (CRS) PHIL 4284 lores

Babies with CRS may also have anemia or hepatitis. About 100,000 cases of CRS occur globally every year.

Doctors have been studying rubella for a long time. Friedrich Hoffmann, a German physician, gave the first clinical description in 1740. Later, in 1814, George de Maton suggested it was a unique disease. He argued it was different from scarlet fever and regular measles. This is why it earned the name "German measles." Because it was studied by German doctors, it was also called Rötheln. These early discoveries helped scientists understand how to identify the virus. Understanding the history of the disease has helped us develop better ways to fight it.

We can prevent rubella using a vaccine. A single dose of the vaccine is more than 95% effective. Most people receive it as part of the MMR vaccine. This combination protects against measles, mumps, and rubella. Vaccination has changed how much rubella affects the world. In the United States, the CDC announced the elimination of rubella in 2004. The World Health Organization declared the Americas free of rubella in 2015. Australia was also declared rubella-free in October 2018.

Rubella number unvaccinated, World, 2023 (cropped)
Rubella number unvaccinated, World, 2023 (cropped)

High vaccination rates create herd immunity, which stops the virus from spreading.

There is currently no specific treatment for rubella. Doctors instead manage the symptoms to make the person more comfortable. For newborn babies with CRS, doctors focus on treating complications. Surgery can sometimes correct heart defects or cataracts. It is important to test women of childbearing age for immunity. If a woman is not immune, she can be vaccinated. However, the MMR vaccine cannot be given during pregnancy because it contains a live virus. Instead, women should be vaccinated as soon as possible after giving birth. This helps keep both mothers and babies safe from the virus.

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Rubella.jpg
File:Cataracts due to Congenital Rubella Syndrome (CRS) PHIL 4284 lores.jpg
Cataracts due to Congenital Rubella...
File:Rubella virus TEM B82-0203 lores.jpg
Rubella virus TEM B82-0203 lores.jpg
File:Rubella number unvaccinated, World, 2023 (cropped).svg
Rubella number unvaccinated, World, 2023...
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