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Jet lag

life science Maturity 11-13 Next article →

Jet lag is a temporary physiological condition caused by a mismatch between your internal biological timing and the external environment. It is officially classified as a circadian rhythm sleep disorder. This occurs when a person travels rapidly across multiple time zones, moving either east or west. Because the body's internal clock is out of sync with the local time of the destination, the person experiences various physical and mental disruptions. This condition is distinct from general travel fatigue, which is often caused by things like dehydration or disrupted routines. Jet lag specifically involves the disruption of the body's natural biological rhythms.

To understand how this happens, we must look at the suprachiasmatic nucleus, or SCN. The SCN is a master clock located within the hypothalamus of the brain. This master clock regulates the body's circadian rhythm, which is the internal cycle of sleep and wakefulness. The SCN receives light information from the retina to stay aligned with the day-night cycle. It then sends signals to peripheral oscillators, which are smaller clocks in tissues and organs like the liver and lungs. When you travel quickly across time zones, these internal rhythms become misaligned with the new environment's light and dark cycles.

Sometimes, a more complex problem called double desynchronisation occurs. This is a misalignment between two different systems. First, the body's internal clocks may not match the external environment of the new time zone. Second, the central master clock in the brain may not match the peripheral clocks in the organs. While the SCN might adjust quickly to new light patterns, the peripheral oscillators in the liver or muscles may lag behind. This internal mismatch between different parts of your own body can impact your health and mood during travel.

There are different ways the body shifts during travel. When traveling west, the body experiences a phase-delay, meaning the circadian cycle shifts later. When traveling east, the body experiences a phase-advance, meaning the cycle shifts earlier. Most travelers find that adjusting to an eastward shift is more difficult than adjusting to a westward one. The speed of adjustment depends on the individual and the direction of travel. On average, it takes approximately one day to reach circadian re-entrainment for every one hour of time zone change.

Historically, the concept of jet lag emerged with the rise of jet aircraft. Before jets, long-distance travel was done by sea or rail, which was too slow to cause these rapid shifts. In 1931, aviator Wiley Post wrote about the effects of flying across time zones in his book, *Around the World in Eight Days*. However, Post and the Federal Aviation Administration did not initially link these symptoms to circadian rhythms. They instead blamed travel fatigue factors like anxiety or dehydration. The specific term "jet lag" first appeared in a Los Angeles Times article on February 13, 1966, written by Horace Sutton.

Symptoms of jet lag can vary widely based on the number of time zones crossed. Common cognitive effects include poor concentration, dizziness, confusion, and anxiety. Many people also experience physical symptoms like headaches, nausea, and irritability. Digestion can be affected as well, leading to indigestion, reduced appetite, or changes in bowel movements. Sleep disturbances are very common, including trouble falling asleep when flying east or early awakening when flying west. Because these symptoms can impact performance, athletes at events like the Olympics often arrive two to four weeks early to adjust.

Jet lag is closely linked to the science of chronobiology and sleep medicine. It is specifically triggered by travel along the east-west axis. For example, a flight moving north or south, such as from Europe to southern Africa, does not typically cause jet lag. However, a shorter flight moving east or west, like from Miami to Phoenix, can cause it. The most powerful tool for resetting the internal clock is light, which acts as a zeitgeber, or a timing signal. The timing and intensity of light exposure help the SCN adjust the body's rhythms to the new local time through a process called entrainment.

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