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Hair follicle

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A hair follicle is a complex organ located within the dermal layer of mammalian skin.

Blausen 0438 HairFollicleAnatomy 02
Blausen 0438 HairFollicleAnatomy 02

It is composed of 20 different cell types, each performing a distinct biological function. These follicles regulate hair growth through intricate interactions involving hormones, neuropeptides, and immune cells. This regulatory system allows different types of hair to grow on various parts of the body. For instance, terminal hairs grow on the scalp, while lanugo hairs cover the bodies of fetuses and some newborns.

Understanding these organs is vital for developmental biology, medicine, and studying human appearance.

The hair follicle functions as part of a larger structure called the pilosebaceous unit. This unit consists of a triad: the hair follicle, a sebaceous gland, and the arrector pili muscle. At the base of the follicle lies the papilla, which contains connective tissue and a capillary loop. Surrounding the papilla is the hair matrix and a root sheath. The root sheath includes an external layer and an internal layer made of three parts: Henle's layer, Huxley's layer, and an internal cuticle. A critical area called the bulge is located in the outer root sheath. This bulge houses LGR5+ stem cells that supply the follicle with new cells and assist in epidermal healing.

Blausen 0438 HairFollicleAnatomy 02
Blausen 0438 HairFollicleAnatomy 02

Hair growth occurs through a series of distinct, sequential stages. The first stage is anagen, the active growth phase, where the hair root divides rapidly. During anagen, hair can grow approximately 1 cm every 28 days. This is followed by catagen, a short transition or regression phase lasting 2 to 3 weeks. During catagen, the follicle converts the hair into a club hair, which is a dead, fully keratinized structure. Next is telogen, a resting phase that lasts about three months. The cycle also includes exogen, the active shedding phase, and kenogen, the period between shedding and new growth.

The length of these growth cycles varies significantly depending on the body part. On the scalp, the anagen phase can last between 2 and 7 years, which is why scalp hair grows so long. In contrast, the cycle for eyebrows is much shorter, with anagen lasting only 4 to 7 months. Typically, about 85% of hair follicles are in the anagen phase at any time. Between 10% and 14% are in telogen, and only 1% to 2% are in catagen. If a person experiences extreme stress, up to 70% of hair may prematurely enter the telogen phase. This specific condition of sudden hair loss is known as telogen effluvium.

Physical characteristics of hair, such as texture and shape, are determined by the follicle's structure. The shape of the dermal papilla, the position of the hair bulb, and the curvature of the follicle all play roles. For example, people of European descent often have elliptical follicles that produce wavy or straight hair. People of African descent often have more curved follicles, resulting in tightly curled hair. Those of Asian descent often have circular follicles that produce straight hair. Diameter also varies by species; a chimpanzee's hair is 101–113 micrometers, while an orangutan's hair is much thicker at 140–170 micrometers.

Changes in the hair follicle can signal various medical conditions or systemic illnesses. Abnormalities in growth or texture can be early indicators of diseases like alopecia, which is hair loss, or hirsutism, which is excess hair growth. Other conditions include lupus erythematosus and various scalp diseases linked to the microbiome. Some disorders, known as the follicular occlusion tetrad, involve chronic inflammation and scarring. This group includes hidradenitis suppurativa, acne conglobata, dissecting cellulitis of the scalp, and pilonidal disease. These conditions are characterized by follicular hyperkeratinization, which leads to the blockage or occlusion of the follicle.

Scientists and doctors also study the follicle to improve hair restoration techniques. Two primary methods used in hair transplantation are Follicular Unit Transplantation (FUT) and follicular unit extraction (FUE). In these procedures, surgeons extract follicular units, which are natural groupings of one to four hairs. These units are taken from donor areas and surgically implanted into a recipient area, such as a balding patch on the scalp. By understanding the biology of the follicle, researchers continue to explore how to treat hair loss and other dermatological issues.

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File:Blausen 0438 HairFollicleAnatomy 02.png
Blausen 0438 HairFollicleAnatomy 02.png
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