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Skin

life science Maturity 9-11 Vital Level 3 Next article →

Skin is the soft, flexible outer tissue that covers the bodies of vertebrate animals. It functions as a vital interface between a living organism and its external environment. This biological barrier serves three primary roles: protection, regulation, and sensation. It acts as the first line of defense against pathogens and prevents excessive water loss. Additionally, skin aids in temperature regulation, insulation, and the production of vitamin D folates.

Dermatoglyphs on Human Skin
Dermatoglyphs on Human Skin

In mammals, the skin is a complex organ of the integumentary system. It is composed of multiple layers of ectodermal tissue. This structure guards underlying muscles, bones, ligaments, and internal organs. The skin also contributes to the formation of various extraskeletal apparatuses. These include the horns of bovids, the antlers of cervids, and the osteoderms of armadillos. Even marine mammals like whales and dolphins possess some hair on their skin.

Elephant skin (3689577529)
Elephant skin (3689577529)

Mammalian skin is organized into two primary layers: the epidermis and the dermis. The epidermis is the outermost layer and provides waterproofing. It acts as a barrier to infection through a stratified squamous epithelium. This layer is made of proliferating basal cells and differentiated suprabasal keratinocytes. Keratinocytes are the most abundant cells, making up 95% of the epidermis. Other important cells include Merkel cells, melanocytes, and Langerhans cells.

FrogSkin
FrogSkin

The epidermis contains several distinct strata, or layers. These include the stratum corneum, stratum lucidum, stratum granulosum, stratum spinosum, and the stratum basale. In the stratum basale, keratinocytes undergo mitosis to create new cells. As these daughter cells move upward through the strata, they undergo cell differentiation. They eventually become anucleated, meaning they lose their nuclei. During this process, they secrete keratin proteins and lipids to create mechanical strength. Finally, cells from the stratum corneum are shed through a process called desquamation.

A thin sheet of fibers called the basement membrane separates the epidermis from the dermis. This membrane controls the movement of cells and molecules between the two layers. It also acts as a reservoir for cytokines and growth factors. These molecules are released during physiological remodeling or tissue repair. The dermis lies beneath the epidermis and consists of connective tissue. It provides tensile strength and elasticity through an extracellular matrix. This matrix is composed of collagen fibrils, microfibrils, and elastic fibers embedded in hyaluronan and proteoglycans.

The dermis is structurally divided into two specific regions. The superficial papillary region contains fingerlike projections called papillae. These projections interdigitate with the epidermis to strengthen the connection between layers. The deeper, thicker reticular region contains a dense concentration of fibers. This region houses hair follicles, sweat glands, sebaceous glands, and blood vessels. It also contains mechanoreceptors, such as nociceptors and thermoreceptors, which provide the senses of touch and heat. Below the dermis lies the subcutaneous tissue, or hypodermis. This layer attaches the skin to bone and muscle and contains 50% of the body's fat.

Skin thickness varies significantly across different parts of the body. In humans, the skin under the eyes is the thinnest at only 0.5 mm. This thinness makes it one of the first areas to show wrinkles. Conversely, the skin on the palms and soles is the thickest at 4 mm. Other vertebrates utilize different skin structures for survival. Reptiles and birds have hard scales or feathers made of beta-keratins. Amphibians have highly permeable skin subject to osmosis and diffusion. For example, chemicals can diffuse through a frog's skin very quickly. Some amphibians also possess granular glands that secrete toxic compounds for defense.

FrogSkin
FrogSkin

Scientific study of skin has a long history. The word "skin" is a borrowing from Old Norse, referring to animal hide or fur. Originally, the term only referred to tanned animal hides. In the past, the word "hide" was commonly used for human skin. Biologists continue to find new information about ancient life through skin fossils. On 11 January 2024, researchers reported the discovery of the oldest known fossilized skin. This specimen is approximately 289 million years old and likely belonged to an ancient reptile.

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🖼️ Images & Media (3)
File:Elephant skin (3689577529).jpg
Elephant skin (3689577529).jpg
File:Dermatoglyphs on Human Skin.jpg
Dermatoglyphs on Human Skin.jpg
File:FrogSkin.png
FrogSkin.png
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