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Vein

life science Maturity 11-13 Next article →

Veins are critical blood vessels within the circulatory system of humans and most other animals. Their primary function is to carry blood back toward the heart. While most veins transport deoxygenated blood from body tissues, there are two notable exceptions. In the pulmonary circulation, pulmonary veins carry oxygenated blood from the lungs to the heart. Similarly, in fetal circulation, veins are used to transport oxygenated blood.

2101 Blood Flow Through the Heart
2101 Blood Flow Through the Heart

Because they can expand to hold large amounts of blood, veins are often called capacitance vessels.

The structure of a vein is defined by three concentric layers known as tunicae. The outermost layer is the tunica externa, or adventitia, which consists of thick connective tissue. The middle layer is the tunica media, made of bands of smooth muscle. The innermost layer is the tunica intima, a thin lining of endothelium.

Figure 40 03 07
Figure 40 03 07

Compared to arteries, veins have a thinner tunica media and a wider internal diameter, called a lumen. This wider lumen and thinner wall allow veins to accommodate significant pressure changes. In fact, nearly 70% of the total blood volume in the human body is held within the veins at any given time.

Veins vary significantly in size and complexity. The smallest vessels are post-capillary venules, which are microscopic and measure between 10 and 30 micrometres in diameter. These lack a smooth muscle layer and are instead supported by cells called pericytes. As they grow to 50 micrometres, they become muscular venules. These eventually merge into small veins, which then feed into medium and large veins.

2106 Large Medium Vein Venule
2106 Large Medium Vein Venule

The largest veins are the superior and inferior vena cava. The superior vena cava drains blood from the head, arms, and chest. The inferior vena cava, which is the larger of the two, drains blood from the legs and abdomen.

Diagram of the human heart (cropped)
Diagram of the human heart (cropped)

To ensure blood moves in only one direction, many veins contain bicuspid valves. These one-way valves are formed by infoldings of the tunica intima. They prevent blood from flowing backward, or regurgitating, due to gravity or low pressure.

Venous valve
Venous valve

When blood attempts to reverse direction, the pressure fills small pockets called valvular sinuses. This action forces the valve leaflets together to seal the vessel. Approximately 95% of these valves are found in small veins measuring less than 300 micrometres. In the lower limbs, these valves work alongside skeletal muscle pumps. When leg muscles contract, they exert pressure on intramuscular veins, driving blood upward toward the heart.

Venous valve 00013
Venous valve 00013

The venous system is organized into three main compartments: deep veins, superficial veins, and perforator veins. Deep veins are located further inside the body and have corresponding arteries. Superficial veins are closer to the skin's surface and do not have matching arteries. Perforator veins act as bridges, draining blood from the superficial veins into the deep veins.

2134 Thoracic Upper Limb Veins
2134 Thoracic Upper Limb Veins

In the legs, the walls of the veins are much thicker than those in the arms to handle different physical demands. While the main veins stay in relatively constant positions, the exact location of other veins varies between different individuals.

Veins often travel in close proximity to arteries. Some arteries are accompanied by a pair of veins called venae comitantes, or satellite veins, which run on either side of the artery. When an artery, vein, and nerve are all enclosed in a single sheath, it is called a neurovascular bundle. This close arrangement serves two important purposes. First, the pulsations of the artery help assist venous blood return. Second, it allows for a counterflow exchange where heat is transferred from the large arteries to the veins. This process helps the body preserve its normal internal heat.

Understanding the venous system also requires looking at specialized networks. There are several venous plexuses, which are groups of veins combined into networks. One example is the Batson venous plexus, which runs through the inner vertebral column and connects thoracic and pelvic veins. Because these specific veins lack valves, they are noted for their role in the metastasis of certain cancers. The venous system also supports specific circulatory routes, such as the coronary circulation for the heart and the renal circulation for the kidneys. These complex pathways ensure that every part of the body is efficiently serviced by the blood flow.

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🖼️ Images & Media (8)
File:Figure 40 03 07.jpg
Figure 40 03 07.jpg
File:Diagram of the human heart (cropped).svg
Diagram of the human heart (cropped).svg
File:2134 Thoracic Upper Limb Veins.jpg
2134 Thoracic Upper Limb Veins.jpg
File:Venous valve 00013.gif
Venous valve 00013.gif
File:Venous valve.svg
Venous valve.svg
File:2101 Blood Flow Through the Heart.jpg
2101 Blood Flow Through the Heart.jpg
File:2106 Large Medium Vein Venule.jpg
2106 Large Medium Vein Venule.jpg
File:William Harvey ( 1578-1657) Venenbild.jpg
William Harvey ( 1578-1657) Venenbild.jpg
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