Nepedia
Back to Discover
Advanced Reader
🧬

Capillary

life science Maturity 9-11 Next article →

Capillaries are the smallest blood vessels in the human body. They are a vital part of the microcirculation system. These vessels typically measure only 5 to 10 micrometres in diameter.

A red blood cell in a capillary, pancreatic tissue - TEM
A red blood cell in a capillary, pancreatic tissue - TEM

Because they are so tiny, they serve as the primary site for exchanging substances between the blood and the surrounding interstitial fluid. This exchange is essential for life. It allows nutrients to reach cells and waste products to be removed. Without this constant movement, our tissues could not function.

The structure of a capillary is incredibly simple. It is composed of only one layer called the tunica intima. This layer consists of a thin wall of simple squamous endothelial cells. These cells form the barrier through which materials must pass. There are two main ways substances move across this wall. Small molecules like water and gases use paracellular transport. This means they move through the tiny spaces between the cells. Larger molecules, such as albumin, use transcellular transport. This process requires the molecules to move directly through the endothelial cells inside small vesicles.

The exchange between capillary and body tissue diagram
The exchange between capillary and body tissue diagram

Capillaries are organized into complex networks called capillary beds. These beds supply specific tissues and organs. The number of capillaries needed depends on how much energy a tissue uses. A more metabolically active tissue will require more capillaries to supply nutrients and carry away waste. Blood flows from the smallest branches of arteries, called arterioles, into the capillaries. From there, it moves into small vessels called venules. These venules then merge into larger veins to return blood to the heart. In some areas, like the mesentery, metarterioles form an extra stage between the arterioles and the capillaries.

Scientists categorize blood capillaries into three distinct types. The first type is continuous capillaries. These have an uninterrupted lining of endothelial cells. They only allow small molecules, like ions and water, to pass through tiny gaps. In the central nervous system, these capillaries have very few transport vesicles. This helps form the blood–brain barrier. The second type is fenestrated capillaries. These have small pores called fenestrae, which is Latin for "windows."

Different Types of Capillaries
Different Types of Capillaries

These pores are 60–80 nanometres in diameter and are covered by a thin diaphragm. They are found in the intestines, pancreas, and kidneys. The third type is the sinusoidal capillary, also known as a discontinuous capillary. These have much wider openings of 30–40 micrometres. They lack a diaphragm and allow even large red and white blood cells to pass.

Sinusoid
Sinusoid

Sinusoids are found in the liver, spleen, and bone marrow.

We can trace the history of our understanding of these vessels back many centuries. A 13th-century manuscript by Ibn Nafis contains the earliest known description. He predicted the existence of tiny passages between the pulmonary artery and the pulmonary vein. These passages were later identified as capillaries by Marcello Malpighi. The word "capillary" comes from the Latin word for "resembling hair." This refers to their tiny, hair-like diameter. The term has been used in English since the mid-17th century. The term can also be used as an adjective to describe "capillary action," where liquid flows without gravity.

Capillary formation is a complex biological process. During early embryonic development, new vessels form through vasculogenesis. This is the production of new endothelial cells that form vascular tubes. As the body grows, it also uses angiogenesis. This is the formation of new capillaries from pre-existing blood vessels. This process is very important in medicine. For example, cancer cells use angiogenesis to help themselves grow by creating more vessels. On the other hand, doctors study how to limit this growth to treat tumors. Issues with the vascular endothelial growth factor (VEGF) can also lead to many different health disorders.

Capillaries are also used in medical testing. Doctors often use capillary blood sampling to monitor health. This is done by making a tiny cut with a tool called a lancet. This allows for the testing of blood glucose, hemoglobin, or pH levels. It is also used to test for infections like HIV or hepatitis B and C. By sampling blood from a finger, doctors can quickly get important information. Understanding how these tiny vessels work helps us understand how the entire human body stays in balance.

2108 Capillary Exchange
2108 Capillary Exchange
698 words

Where will your curiosity go next?

Keep exploring at your chosen reading level.

🖼️ Images & Media (5)
File:A red blood cell in a capillary, pancreatic tissue - TEM.jpg
A red blood cell in a capillary,...
File:Different Types of Capillaries.jpg
Different Types of Capillaries.jpg
File:Sinusoid.jpeg
Sinusoid.jpeg
File:The exchange between capillary and body tissue diagram.svg
The exchange between capillary and body...
File:2108 Capillary Exchange.jpg
2108 Capillary Exchange.jpg
More to explore

✨ What else?

Related topics you might enjoy

🔬 Go deeper

More advanced topics to explore

🪜 Step back

Simpler topics to build understanding

What is Nepedia?

A free, ad-free encyclopedia for children. Every article is written at five reading levels, so the same page works for a five-year-old and a fifteen-year-old — use the level switcher above to see this one change. No account needed to read.