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Urinary tract infection

life science Maturity 11-13 Next article →

A urinary tract infection, or UTI, is an infection that affects the body's urinary system. This system consists of the kidneys, the bladder, and the urethra, which is the tube that carries urine out of the body.

Bladder Infection
Bladder Infection

UTIs are extremely common, with approximately 400 million cases occurring every year. They are the most common bacterial infection found in women.

Urinary Tract Infection(UTI) - Project Wiki Women
Urinary Tract Infection(UTI) - Project Wiki Women

Understanding how these infections work is vital for medical care.

Medical professionals classify these infections based on where they occur. A lower urinary tract infection affects the bladder or the urethra. When the infection is specifically in the bladder, it is called cystitis. An upper urinary tract infection affects the kidneys. This specific type of kidney infection is known as pyelonephritis.

Pyuria2011
Pyuria2011

Some infections are also classified by their complexity. An uncomplicated UTI usually occurs in healthy, premenopausal women. A complicated UTI might involve a male patient, a pregnant woman, or someone with diabetes.

The mechanism of infection usually begins with bacteria entering the urinary tract. Most often, these bacteria travel from the bowel to the urethra.

UPEC adhered to BEC
UPEC adhered to BEC

The most common cause is a bacterium called uropathogenic Escherichia coli, or UPEC. Once UPEC reaches the bladder, it attaches itself to the bladder wall. The bacteria can then form a biofilm, which is a protective layer that helps them resist the body's immune response. While E. coli causes 75% of uncomplicated UTIs, other bacteria like Klebsiella pneumoniae can cause infections, especially in those using a catheter.

Symptoms of a UTI vary depending on the location and the person's age. Lower UTIs often cause burning or pain during urination. They can also cause pain in the lower abdomen or a frequent urge to urinate. Upper UTIs, or pyelonephritis, present more systemic symptoms. These include fever, nausea, vomiting, or flank pain in the side of the body. In rare cases, a person's urine may appear bloody or contain visible pus.

Bacteriuria pyuria 4
Bacteriuria pyuria 4

Children and the elderly often show different signs of infection. In very young children, a fever might be the only symptom. Infants may also feed poorly, vomit, or sleep more. About 1 in 400 infants with a UTI also have bacterial meningitis. In the elderly, symptoms are often vague. They might experience fatigue, incontinence, or a change in mental status, such as delirium. Some elderly patients may even present with sepsis, which is an infection of the blood.

History shows that humans have recognized these issues for millennia. The first documented description of a UTI is found in the Ebers Papyrus. This ancient Egyptian document dates back to approximately 1550 BC.

Since then, diagnostic methods have become much more precise. Doctors now use urinalysis to check for substances like nitrates or leukocyte esterase. They also use urine microscopy to look for red blood cells, white blood cells, or bacteria. A urine culture can confirm an infection if it shows a high count of bacterial colonies.

Treatment depends on the severity and type of the infection. Most uncomplicated cases are treated with a short course of antibiotics. However, resistance to many common antibiotics is currently increasing. Complicated cases might require longer courses or intravenous antibiotics delivered through a vein. For people with recurrent infections, doctors may prescribe methenamine. Postmenopausal women might also use vaginal estrogen replacement to help prevent infections. These treatments aim to clear the bacteria and protect the urinary tract from future issues.

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Pyuria2011.JPG
File:UPEC adhered to BEC.jpg
UPEC adhered to BEC.jpg
Urinary Tract Infection(UTI) - Project...
File:Bladder Infection.png
Bladder Infection.png
File:Bacteriuria pyuria 4.jpg
Bacteriuria pyuria 4.jpg
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