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Ovarian cancer

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Ovarian cancer is a serious disease caused by the growth of cancerous tumors.

Site of ovarian cancer
Site of ovarian cancer

These tumors can originate within the ovary itself. They may also begin in nearby structures, such as the fallopian tubes or the inner lining of the abdomen. The ovary is composed of three specific cell types: epithelial cells, germ cells, and stromal cells. When these cells become abnormal, they begin to divide uncontrollably. This process creates a tumor that can eventually invade or spread to other parts of the body.

Ovarian carcinoma
Ovarian carcinoma

The mechanism of the disease often involves the spread of cells, known as metastases. Cancer cells can travel to the lining of the abdomen, lymph nodes, lungs, or the liver. Because the ovaries are located deep in the pelvis, tumors are often quite large by the time they are found. As a mass grows, it may press on other organs in the abdominopelvic area. This pressure can cause significant pain or even ovarian torsion, where the ovary twists. In advanced stages, fluid can accumulate in the abdomen, a condition called ascites.

POvarianCA
POvarianCA

There are several distinct types of ovarian cancer based on the cells involved. Epithelial ovarian carcinoma is the most common, making up more than 95% of all cases. Within this category, there are five main subtypes. High-grade serous carcinoma (HGSC) is the most frequent subtype of epithelial cancer. Other, less common types include germ cell tumors and sex cord-stromal tumors. In children and adolescents, sex cord-stromal tumors can actually produce hormones. This might lead to the premature development of secondary sex characteristics.

Incidence of ovarian cancers by histopathology
Incidence of ovarian cancers by histopathology

Scientists have identified many risk factors that influence the likelihood of developing this cancer. Age is a major factor, as most cases occur after menopause. Risk is also linked to the number of times a woman has ovulated during her life. For example, women who began ovulation at a young age or reached menopause later face higher risks. Conversely, factors like pregnancy and breastfeeding can decrease risk. This is because ovulation is suppressed during these times. Other risks include obesity, diabetes mellitus, and the use of hormone replacement therapy.

Ovarian tumors by incidence and cancer risk
Ovarian tumors by incidence and cancer risk

Genetics play a critical role in about 10% of all cases. The most significant genetic risk comes from mutations in the BRCA1 or BRCA2 genes. These mutations can be inherited from either the mother or the father. A woman with a BRCA1 mutation has a lifetime risk of 15% to 45%. A woman with a BRCA2 mutation has a lifetime risk between 10% and 40%. Certain family syndromes, such as Lynch syndrome, also increase the risk. For those with these inherited mutations, cancer often develops about 15 years earlier than in other cases.

BRCA1 and BRCA2 mutations and absolute cancer risk
BRCA1 and BRCA2 mutations and absolute cancer risk

The impact of ovarian cancer is significant in terms of global health statistics. In 2020, approximately 313,000 new cases were reported. In the United States, it is the second-most common gynecologic cancer. It also causes more deaths than any other cancer of the female reproductive system. In 2019, there were 13,445 deaths from this disease in the U.S. alone. Globally, deaths from ovarian cancer increased by 84.2% between 1990 and 2017. The overall five-year survival rate in the United States is currently 52%.

Ovary cancer world map - Death - WHO2004
Ovary cancer world map - Death - WHO2004

Understanding these connections helps doctors develop better treatment and prevention strategies. A diagnosis is usually confirmed through a biopsy, where tissue is removed during surgery. If the cancer is caught in an early stage, it is often curable. Common treatments include a combination of surgery, radiation therapy, and chemotherapy. While screening is not recommended for women at average risk, those at very high risk may choose to have their ovaries removed preventively. Success in treatment often depends on the specific subtype and the extent of the disease.

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🖼️ Images & Media (25)
En.Video-Ovarian cancer.webm
File:Site of ovarian cancer.png
Site of ovarian cancer.png
File:Mature cystic teratoma of ovary.jpg
Mature cystic teratoma of ovary.jpg
File:PedigreechartC.png
PedigreechartC.png
File:BRCA1 and BRCA2 mutations and absolute cancer risk.jpg
BRCA1 and BRCA2 mutations and absolute...
Ovarian Cancer - Project Wiki Women.mpg
File:POvarianCA.png
POvarianCA.png
File:Serous carcinoma cytology.jpg
Serous carcinoma cytology.jpg
File:Incidence of ovarian cancers by histopathology.png
Incidence of ovarian cancers by histopathology.png
File:Ovarian carcinoma.JPG
Ovarian carcinoma.JPG
File:Serous carcinoma (3061775966).jpg
Serous carcinoma (3061775966).jpg
File:Small cell carcinoma of the ovary hypercalcemic type - high mag.jpg
Small cell carcinoma of the ovary...

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