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Local anesthesia

life science Maturity 11-13 Next article →

Local anesthesia is a way to stop feeling in one part of the body.

It helps people stay calm during dental work or surgery. You do not have to fall asleep like you do with general anesthesia. This can be safer for some people. For example, it is often used during a cesarean section. It helps a patient feel less pain or distress.

This medicine works by blocking tiny paths in your nerves. These paths are called voltage-gated sodium channels.

Think of these channels like small gates in a wall. When the medicine blocks these gates, signals cannot pass through. This stops the pain signals from reaching your brain. The effect is reversible, so the feeling eventually comes back. This process is called analgesia, which means a loss of pain.

People have been finding new ways to do this for a long time. In 1884, Karl Koller used cocaine as the first local anesthetic.

Later, August Bier performed the first spinal anesthesia in 1898. James Leonard Corning also studied epidural techniques. In 1923, Gaston Labat helped make these methods standard in America. He was called the "father of regional anesthesia in America."

Doctors use many different ways to give this medicine. Topical anesthesia means putting it on the skin or mucous membranes. Infiltration anesthesia involves a direct injection into the tissue.

A peripheral nerve block is an injection near specific nerves. Some doctors even use spinal or epidural techniques. These are called neuraxial anesthesia. They can numb much larger areas like a whole leg.

There are two main types of these medicines. They are called aminoamide and aminoester local anesthetics.

Some modern medicines are related to cocaine. However, they are different because they are not for abuse. They also do not cause high blood pressure. Some medicines, like Ropivacaine, can cause weak vasoconstriction. This means they make blood vessels tighten a little bit.

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