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Lactose

physical science Maturity 11-13 Next article →

Lactose is a disaccharide, which is a type of sugar made of two smaller sugar units. Its chemical formula is C12H22O11. It is a white, water-soluble solid that tastes mildly sweet. The name comes from the Latin word for milk, *lac*, plus the suffix *-ose* used for sugars. This substance is found in the milk of many different mammal species. It serves as a vital energy source for nursing infants.

Alpha-lactose-from-xtal-3D-balls
Alpha-lactose-from-xtal-3D-balls

Lactose is composed of two specific sugars: galactose and glucose. These two units are joined by a β-1→4 glycosidic linkage. This means the galactose and glucose are connected at specific points in their molecular structures. Because of how they are joined, lactose can exist in different forms. It can be α-lactose or β-lactose depending on the shape of the glucose ring. The galactose part stays in the β-pyranose form. This complex structure determines how the sugar behaves in chemical reactions.

To use this sugar for energy, the body must break it down. This process is called hydrolysis. In the digestive system, the intestinal villi secrete an enzyme called lactase, or β-D-galactosidase. This enzyme acts like a pair of molecular scissors. It cleaves the lactose molecule into its two subunits, glucose and galactose. Once separated, these simple sugars are small enough to be absorbed into the bloodstream. If the enzyme is not present, the lactose remains whole and moves through the gut. This can provide food for gas-producing bacteria, causing bloating or diarrhea.

Lactose concentrations vary significantly across the animal kingdom. For example, bovine milk, or cow milk, contains about 4.8% lactose by mass. Rhesus macaque monkeys have a much higher concentration at 8%. However, some mammals, such as bears, produce milk that contains no lactose at all. In the dairy industry, lactose is often extracted from whey. Whey is the liquid left after milk is curdled to make cheese. Scientists can purify lactose from whey permeate by evaporating it to 60–65% solids and then crystallizing it as it cools.

Humans have studied this sugar for hundreds of years. In 1633, physician Fabrizio Bartoletti published a method to isolate a substance he called the "manna of whey." In 1780, Carl Wilhelm Scheele identified it as a sugar. Later, in 1812, Heinrich Vogel discovered that glucose is produced when lactose is hydrolyzed. In 1843, the chemist Jean Baptiste André Dumas gave it the name "lactose." By 1856, Louis Pasteur crystallized galactose, the other part of the sugar. Finally, Emil Fischer established the exact molecular configurations of the component sugars by 1894.

Lactose has many specific biological and chemical properties. Its sweetness is relatively low, measuring only 0.2 to 0.4 compared to sucrose. When fully digested, it provides 4 kcal/g of energy. However, if it is not fully digested, its caloric value can range from 2 to 4 kcal/g. It also has a glycemic index between 46 and 65. This is lower than the index for glucose, which is 100 to 138. Interestingly, lactose has low cariogenicity, meaning it is less likely to cause tooth decay. This is because oral bacteria do not ferment it rapidly.

Today, lactose is used in many different industries. In the food industry, it is used in infant formula to match the composition of human milk. It is also used to sweeten certain types of beer, like milk stouts. In the pharmaceutical industry, lactose is a common ingredient in tablets and capsules. It acts as a carrier or stabilizer for various drugs, such as atorvastatin. Because it is a stable solid, it helps hold medicine together. It can even be used to help the body absorb minerals like calcium and magnesium.

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