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Lactic acid

physical science Maturity 5-7 Next article →

Lactic acid is a vital organic acid with the molecular formula C3H6O3. In its solid state, it appears as a white substance. It is miscible with water, meaning it dissolves easily to form a colorless solution. Chemically, it is classified as an alpha-hydroxy acid (AHA). This term describes a molecule where a hydroxyl group sits adjacent to a carboxyl group. This specific structure makes it much more acidic than acetic acid. In fact, it is ten times more acidic because of intramolecular hydrogen bonding. In a solution, the acid can lose a proton to become a lactate ion. This ion is also known as 2-hydroxypropanoate.

Blood values sorted by mass and molar concentration
Blood values sorted by mass and molar concentration

Lactic acid is a chiral molecule, which means it exists in two different mirror-image forms called enantiomers. One form is known as (S)-lactic acid, or (+)-lactic acid. The other is (R)-lactic acid, or (−)-lactic acid. When these two forms exist in equal amounts, the mixture is called racemic lactic acid. The specific type of acid produced depends on its source. For example, fermentation of milk often produces a racemic mixture. However, certain bacteria produce only the (S) form. In animal muscles, the (R) enantiomer is produced. This muscle-derived version is sometimes called "sarcolactic" acid, a name taken from the Greek word for flesh.

In the human body, lactic acid plays a critical role in energy metabolism. During intense exercise like sprinting, the demand for energy is very high. Cells break down glucose into a substance called pyruvate. Normally, cells use oxygen to turn pyruvate into energy through the Krebs cycle. However, if oxygen supply is limited, the body uses fermentation to keep going. An enzyme called lactate dehydrogenase (LDH) reduces pyruvate into lactate. This reaction uses NADH as an electron donor and regenerates NAD+. This regeneration is essential because it allows glycolysis to continue producing energy under anaerobic conditions.

Blood values sorted by mass and molar concentration
Blood values sorted by mass and molar concentration

Lactate does not simply build up indefinitely in the body. It is constantly being produced and removed. The concentration of blood lactate is usually low at rest. During intense exertion, it can rise to over 20mM. It can reach as high as 25mM immediately afterward. The body manages these levels through several mechanisms. These include monocarboxylate transporters and the oxidative capacity of different tissues. Once produced, lactate can be used in two main ways. Well-oxygenated cells in the heart, brain, and muscles can oxidize it back into pyruvate. Alternatively, the liver can convert it into glucose through a process called gluconeogenesis via the Cori cycle.

Industrial production of lactic acid relies on two main methods: fermentation and chemical synthesis. Most industrial lactic acid, between 70% and 90%, is produced through bacterial fermentation. Bacteria such as Lactobacillus casei and Lactococcus lactis consume carbohydrates like glucose, sucrose, or galactose. There are two types of bacteria used in this process. Homofermentative bacteria produce two moles of lactate from one mole of glucose. Heterofermentative species produce one mole of lactate, along with carbon dioxide and acetic acid or ethanol. Chemical synthesis is another option. This involves reacting acetaldehyde with hydrogen cyanide to create lactonitrile, which is then hydrolyzed.

Blood values sorted by mass and molar concentration
Blood values sorted by mass and molar concentration

History shows how our understanding of this acid has grown. The Swedish chemist Carl Wilhelm Scheele first isolated lactic acid in 1780 from sour milk. In 1808, Jöns Jacob Berzelius discovered that muscles also produce it during exertion. Later, in 1856, Louis Pasteur discovered the role of Lactobacillus in its synthesis. Johannes Wislicenus finally established its chemical structure in 1873. Even political history has touched this science. During the era of the Warsaw Pact, the Soviet Union faced shortages of other acids. They invested heavily in developing efficient Lactobacillus strains to produce lactic acid from molasses. This made lactic acid a much cheaper alternative to citric acid.

Today, the global demand for lactic acid is expanding rapidly. The industry sees an annual growth rate of 5% to 8%. This growth is driven by the need for biodegradable plastics and green solvents. Worldwide production exceeded 1.5 million tonnes by the early 2020s. This is a massive increase from the 275,000 tonnes produced in 2006. Major companies like NatureWorks LLC lead this production. One of their largest facilities is located in Blair, Nebraska. It has a production capacity of about 140,000 tonnes per year. This facility provides the materials needed for many biodegradable packaging and fiber applications.

Blood values sorted by mass and molar concentration
Blood values sorted by mass and molar concentration
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