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Kinetoplastid

life science Maturity 11-13 Next article →

Kinetoplastids are a unique group of flagellated protists. They belong to the phylum Euglenozoa. These microscopic organisms are defined by a very special structure called a kinetoplast. This organelle is a dense granule that contains a massive amount of DNA. Kinetoplastids play many roles in the natural world. Some species live freely in soil or water. Others are parasites that live inside humans and animals. These parasites are responsible for several very serious diseases.

2023 Kinetoplastid
2023 Kinetoplastid

The internal structure of a kinetoplastid is quite complex. They are eukaryotic cells, meaning they have standard organelles like a nucleus and a Golgi apparatus. The most distinctive feature is the kinetoplast itself. This granule sits inside the cell's single mitochondrion. It is made of a network of circular DNA molecules. These molecules are connected to structural proteins and enzymes called DNA and RNA polymerases. The kinetoplast is located right at the base of the cell's flagellum. It connects to the flagellum basal body through a special cytoskeletal structure.

2023 Kinetoplastid
2023 Kinetoplastid

To maintain their shape, kinetoplastids use a sturdy cytoskeleton. This system is primarily built from microtubules, which are tiny protein tubes. These microtubules form a very regular pattern called the sub-pellicular array. This array runs parallel just beneath the cell surface. It follows the long axis of the cell to provide stability. Other specialized microtubules, known as rootlet microtubules, are also present. While they can form actin microfilaments, the exact role of actin is not yet clear. This internal framework helps the cell manage its movement and structure.

2023 Kinetoplastid
2023 Kinetoplastid

Movement and feeding are handled by the flagella. All kinetoplastids possess at least one flagellum. The number of flagella depends on the specific group. For example, members of the order Trypanosomatida have only one flagellum. However, members of the order Bodonida typically have two. In species with two flagella, one is often a leading flagellum and the other is a trailing flagellum. The trailing flagellum might even attach to the side of the cell. These tails allow the organism to swim or attach to surfaces. The bases of these flagella sit in a specialized pocket that also contains the cytostome, or feeding structure.

2023 Kinetoplastid
2023 Kinetoplastid

Scientists classify kinetoplastids into two main subclasses. These are the Metakinetoplastina and the Prokinetoplastina. They are also divided into two traditional groups. The first is the biflagellate Bodonidae, which has two flagella. The second is the uniflagellate Trypanosomatidae, which has one. The Trypanosomatidae are especially notable because many of their genera are exclusively parasitic. One common free-living genus is Bodo, which feeds on bacteria. Another important genus is Cryptobia. A well-known parasitic genus is Leishmania.

2023 Kinetoplastid
2023 Kinetoplastid

The history of studying these organisms involves many important scientists. Bronislaw M. Honigberg first defined the group in 1963. He created the taxonomic names Kinetoplastida and Kinetoplastea. There is still no total consensus on which name to use. Kinetoplastea is often used for the class, while Kinetoplastida is often used for the order. Lynn Margulis studied them in 1974 and initially accepted Kinetoplastida as an order. She later placed it as a class. Using Kinetoplastida as an order can be confusing. This is because the older name Trypanosomatida, created by Kent in 1880, is often used instead.

2023 Kinetoplastid
2023 Kinetoplastid

Understanding the life cycles of these organisms is vital for medicine. Trypanosomatids can have very simple life cycles in one host. They can also have complex cycles that move through two different hosts. During these cycles, they may undergo dramatic morphological changes. Some species, like Trypanosoma brucei and Leishmania major, may undergo meiosis. This is a part of a likely sexual cycle. These organisms cause significant health issues. Species of Trypanosoma cause sleeping sickness and Chagas disease. Species of Leishmania cause leishmaniasis.

2023 Kinetoplastid
2023 Kinetoplastid
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