Nepedia
Back to Discover
Advanced Reader
🧬

Ileum

life science Maturity 11-13 Next article →

The ileum is the final section of the small intestine in most higher vertebrates. This includes mammals, reptiles, and birds. It follows the duodenum and the jejunum in the digestive tract. In humans, the ileum is approximately 2 to 4 meters long. The environment inside the ileum is usually neutral or slightly basic. This means the pH level stays between 7 and 8. The name is derived from the Greek word *eileos*. This word refers to a specific medical condition known as ileus.

The primary function of the ileum is to finish the work of nutrient absorption. It absorbs vitamin B12 and bile salts. It also absorbs any products of digestion that the jejunum did not catch. To do this effectively, the ileum uses a massive surface area. The walls are covered in folds. Each fold has many tiny, finger-like projections called villi. The cells lining these villi have even smaller projections called microvilli. This structure allows for the adsorption of enzymes and the absorption of nutrients.

Inside the villi, specialized structures help move nutrients into the body. Large numbers of capillaries carry amino acids and glucose to the liver via the hepatic portal vein. Small lymph vessels called lacteals are also present in the villi. These lacteals absorb fatty acids and glycerol, which are the products of fat digestion. The ileum also uses enzymes to finish breaking down food. Cells in the lining secrete protease and carbohydrase enzymes into the lumen. These enzymes help complete the digestion of proteins and carbohydrates.

The wall of the ileum consists of four distinct layers. The innermost layer is the mucous membrane. This layer contains five specific types of cells. Enterocytes with microvilli digest and absorb nutrients. Goblet cells secrete mucin to lubricate the organ walls. Paneth cells are common in the terminal ileum and release antimicrobial substances like lysozyme. Microfold cells transport antigens to the immune system. Finally, enteroendocrine cells secrete hormones such as gastrin, secretin, and cholecystokinin.

Below the mucosa, the ileum has other complex layers. There is a lamina propria made of loose connective tissue. This area contains Peyer's patches, which are large aggregates of lymphoid tissue. These patches are a distinctive feature of the ileum and help with immunity. Next is the submucosa, which contains large blood vessels and the submucosal plexus. This plexus is part of the enteric nervous system. The outer layers include the muscularis mucosae and an external muscular layer. This muscular layer has two parts: an inner circular layer and an outer longitudinal layer. Between them sits the myenteric plexus.

Movement through the ileum is controlled by muscular contractions. The two layers of smooth muscle create waves called peristalsis. This process pushes the chyme, or partly digested food, along the tract. The ileum ends at the ileocecal junction. Here, the terminal ileum meets the cecum of the large intestine. This connection is managed by the ileocecal valve (ICV). The valve prevents the backflow of ingesta. It also helps manage the pressure between the jejunum and the cecum. In horses, a disturbance in this balance can cause colic.

The development of the ileum is a complex process in the embryo. It begins as part of the midgut in the primitive gut tube. By the fifth week of life, the ileum grows very rapidly. It forms a U-shaped fold called the primary intestinal loop. This loop grows so fast that it actually protrudes through the umbilicus. Between weeks six and ten, the small intestine rotates anticlockwise. By week 10, the loop retracts back into the abdomen. In about 2% to 4% of humans, a connection called the vitelline duct fails to close. This can leave a remnant known as Meckel's diverticulum.

618 words

Where will your curiosity go next?

Keep exploring at your chosen reading level.

More to explore

🔬 Go deeper

More advanced topics to explore

🪜 Step back

Simpler topics to build understanding

What is Nepedia?

A free, ad-free encyclopedia for children. Every article is written at five reading levels, so the same page works for a five-year-old and a fifteen-year-old — use the level switcher above to see this one change. No account needed to read.