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Small intestine

life science Maturity 9-11 Next article →

The small intestine is a vital organ within the gastrointestinal tract. It is located between the stomach and the large intestine. Its primary purpose is the absorption of nutrients from food. This process provides the body with energy and the building blocks for growth. Although it is called "small," this name refers to its narrow diameter. In reality, the small intestine is much longer than the large intestine.

Blausen 0817 SmallIntestine Anatomy
Blausen 0817 SmallIntestine Anatomy

Digestion in the small intestine is a complex chemical process. It begins when the pyloric sphincter allows food to enter the duodenum. The duodenum is the shortest section and is shaped like a "C." It receives gastric chyme from the stomach. The pancreas and liver also send digestive juices here. The pancreas provides enzymes like trypsin and chymotrypsin to break down proteins. The liver provides bile to help emulsify fats.

Small intestine low mag
Small intestine low mag

To protect the body, the duodenum must neutralize strong stomach acids. Brunner's glands in the duodenum produce a mucus-rich, alkaline secretion. This secretion contains bicarbonate. The pancreas also releases bicarbonate into the duodenum. These two sources work together to neutralize the acid in the chyme. This step is essential for the chemical environment needed for enzymes to function. The hormone secretin helps promote this release of bicarbonate from the pancreas.

Cross Section of a Small Intestine
Cross Section of a Small Intestine

The small intestine is divided into three distinct structural regions. The first is the duodenum, which prepares food for absorption. The second is the jejunum, which is the midsection of the organ. The jejunum is about 2.5 meters long and is specialized for nutrient absorption. It uses enterocytes to absorb small particles like sugars and amino acids. The third section is the ileum, which is the final part. The ileum is approximately 3 meters, or 9.8 feet, long. It absorbs vitamin B12, bile salts, and any remaining nutrients.

Absorption of glucose in the small intestine
Absorption of glucose in the small intestine

To maximize absorption, the inner wall of the intestine is not smooth. It features permanent wrinkles called circular folds. From these folds, microscopic finger-like protrusions called villi extend. The individual cells on these villi have even smaller projections called microvilli. These three structures greatly increase the total surface area of the mucosa. The human small intestinal mucosa has an average surface area of 30 to 200 square meters. This massive surface area allows for efficient nutrient uptake. Each villus contains a network of capillaries and lymphatic vessels called lacteals.

Absorption of glucose in the small intestine
Absorption of glucose in the small intestine

Different nutrients follow specific pathways during absorption. Amino acids and carbohydrates enter the bloodstream through the capillaries. Lipids are absorbed into the lacteals. Some nutrients move through the wall via diffusion or active transport. For example, glucose and amino acids use co-transport. Fructose is absorbed through facilitated diffusion. Water is absorbed throughout the intestine via osmosis. Specific items like iron and folate are absorbed primarily in the duodenum. Vitamin B12 requires a protein called intrinsic factor to be absorbed in the ileum.

Small intestine low mag
Small intestine low mag

The development of the small intestine is a remarkable biological event. It begins from the midgut of the primitive gut tube. By the fifth week of life, the ileum grows very rapidly. This growth creates a U-shaped fold called the primary intestinal loop. This loop grows so fast that it protrudes through the umbilicus. By week 10, the loop retracts back into the abdomen. During this time, the intestine rotates anticlockwise and then rotates another 180 degrees. This complex movement creates the necessary twisted shape for the digestive system.

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🖼️ Images & Media (4)
File:Blausen 0817 SmallIntestine Anatomy.png
Blausen 0817 SmallIntestine Anatomy.png
File:Small intestine low mag.jpg
Small intestine low mag.jpg
File:Cross Section of a Small Intestine.png
Cross Section of a Small Intestine.png
File:Absorption of glucose in the small intestine.svg
Absorption of glucose in the small intestine.svg
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