Nepedia
Back to Discover
Advanced Reader
🧬

DNA

life science Maturity 9-11 Vital Level 3 Next article →

Deoxyribonucleic acid, commonly known as DNA, is a vital polymer that serves as the blueprint for life. It carries the essential genetic instructions for the development, growth, functioning, and reproduction of all known organisms and many viruses. DNA belongs to a group of molecules called nucleic acids. Along with proteins, lipids, and complex carbohydrates, nucleic acids are one of the four major types of macromolecules necessary for life.

DNA Structure+Key+Labelled.pn NoBB
DNA Structure+Key+Labelled.pn NoBB

The structure of DNA is a double helix, which looks like a twisted ladder. This molecule is made of two long chains called polynucleotides. Each polynucleotide is built from smaller units called nucleotides. A single nucleotide consists of three parts: a nitrogen-containing nucleobase, a five-carbon sugar called deoxyribose, and a phosphate group.

DNA chemical structure
DNA chemical structure

These nucleotides are linked together in a long chain. They form a sugar-phosphate backbone through covalent bonds known as phosphodiester linkages. These bonds connect the sugar of one nucleotide to the phosphate of the next.

The two strands of the double helix are held together by the nucleobases. There are four types of bases: adenine (A), thymine (T), cytosine (C), and guanine (G). These bases follow specific rules called complementary base pairing. Adenine always pairs with thymine using two hydrogen bonds.

Base pair AT
Base pair AT

Guanine always pairs with cytosine using three hydrogen bonds.

Base pair GC
Base pair GC

The bases are divided into two chemical groups. The purines are adenine and guanine, which have double-ring structures. The pyrimidines are cytosine and thymine, which have single-ring structures.

DNA animation
DNA animation

DNA strands have a specific orientation called directionality or polarity. Each strand has a 5′ end and a 3′ end. The 5′ end features a phosphate group attached to the fifth carbon of the sugar. The 3′ end has a free hydroxyl group attached to the third carbon. Because the two strands run in opposite directions, they are described as being antiparallel. This orientation is crucial for how the molecule interacts with other biological systems.

Phosphate backbone
Phosphate backbone

In eukaryotic organisms, such as animals, plants, and fungi, DNA is organized into long structures called chromosomes. Most of this DNA is stored inside the cell nucleus as nuclear DNA. Some DNA is also found in the mitochondria or the chloroplasts. To fit inside a cell, the DNA must be tightly packed. Chromatin proteins, such as histones, help compact and organize the DNA.

Nucleosome1
Nucleosome1

This compacting helps control which parts of the DNA are used by the cell. In contrast, prokaryotes like bacteria store their DNA in the cytoplasm using circular chromosomes.

Branch-dna-single
Branch-dna-single

DNA is a dynamic molecule that must be copied to allow life to continue. This occurs through DNA replication, where the two strands separate and act as templates to create new strands. This process ensures that when a cell divides, each daughter cell receives a complete set of chromosomes.

DNA replication en
DNA replication en

DNA also facilitates the creation of RNA through a process called transcription. During transcription, DNA acts as a template to build RNA strands. In this process, the base uracil (U) is used in RNA instead of thymine (T). These RNA strands then specify the sequence of amino acids to build proteins through translation.

Scientists have discovered many ways to manipulate or understand DNA. Some bacteria use modified bases, such as 5-methylcytosine, to protect themselves from viruses. The stability of the DNA double helix can be affected by its environment. For example, high temperatures or high pH levels can cause the strands to separate, a process called melting. The strength of the bond between the strands depends on the length of the molecule and its GC-content. DNA with more guanine and cytosine pairs is generally more stable than DNA with more adenine and thymine pairs.

604 words

Where will your curiosity go next?

Keep exploring at your chosen reading level.

🖼️ Images & Media (30)
File:DNA Structure+Key+Labelled.pn NoBB.png
DNA Structure+Key+Labelled.pn NoBB.png
File:Phosphate backbone.jpg
Phosphate backbone.jpg
File:DNA chemical structure.svg
DNA chemical structure.svg
File:DNA animation.gif
DNA animation.gif
File:DNA-ligand-by-Abalone.png
DNA-ligand-by-Abalone.png
File:Base pair GC.svg
Base pair GC.svg
File:Base pair AT.svg
Base pair AT.svg
File:Human karyotype with bands and sub-bands.png
Human karyotype with bands and sub-bands.png
File:Dnaconformations.png
Dnaconformations.png
File:Parallel telomere quadruple.png
Parallel telomere quadruple.png
File:Branch-dna-single.svg
Branch-dna-single.svg
File:Branch-DNA-multiple.svg
Branch-DNA-multiple.svg

+ 18 more

More to explore

🔬 Go deeper

More advanced topics to explore

🪜 Step back

Simpler topics to build understanding

What is Nepedia?

A free, ad-free encyclopedia for children. Every article is written at five reading levels, so the same page works for a five-year-old and a fifteen-year-old — use the level switcher above to see this one change. No account needed to read.