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COVID-19

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COVID-19 is a contagious disease caused by a specific virus known as SARS-CoV-2.

Coronavirus virion structure
Coronavirus virion structure

This virus belongs to a large group called coronaviruses. The disease became a global pandemic when it spread across the entire world. In March 2020, the World Health Organization (WHO) declared a global health emergency. This emergency status lasted until May 2023. Understanding this virus is vital because it affects many different systems in the human body.

The virus operates through a specific biological mechanism to infect host cells.

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Fpubh-08-00383-g003

The SARS-CoV-2 particle uses a surface protein called a spike protein (S) to find its target. It looks for a specific receptor called angiotensin-converting enzyme 2, or ACE2. This receptor is most abundant on the surface of type II alveolar cells in the lungs. Once the spike protein connects to the ACE2 receptor, the virus can enter the cell. This process allows the virus to hijack the cell's machinery to replicate itself.

Transmission of the virus occurs through several different pathways.

Transmission of COVID-19
Transmission of COVID-19

People can breathe in infectious particles that are suspended in the air. This risk is especially high when people are close together in indoor spaces. Small airborne particles can travel over long distances. Transmission also happens when a person touches their eyes, nose, or mouth after touching contaminated surfaces. People can remain contagious for up to 20 days. Importantly, many people can spread the virus even if they show no symptoms at all.

Symptoms of COVID-19 vary greatly depending on the individual.

Graph of Covid-19 Infection Fatality Ratio by age
Graph of Covid-19 Infection Fatality Ratio by age

Symptoms usually begin between one and 14 days after exposure. Common signs include fever, fatigue, cough, and breathing difficulties. Many people also experience a loss of smell or taste. About 81% of patients develop mild to moderate symptoms, such as mild pneumonia. However, 14% develop severe symptoms like hypoxia, which is low oxygen in the blood. Only 5% of patients develop critical symptoms like respiratory failure or multi-organ dysfunction.

History shows that the first known case was identified in Wuhan, China, in December 2019. Most scientists believe the virus emerged through natural zoonosis. This means the virus jumped from animals to humans. This process is consistent with other outbreaks like SARS-CoV-1 and MERS-CoV. Factors like climate change and wildlife trade may have increased this risk. To prevent social stigma, the WHO issued official names in February 2020. They chose COVID-19 as shorthand for "coronavirus disease 2019."

Beyond the lungs, the virus can cause serious complications in other systems.

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Ijms-21-05932-g003

Cardiovascular complications can include heart inflammation, arrhythmias, or thrombosis. Some people experience neurological issues like seizures, stroke, or encephalitis. About 20% to 30% of patients show signs of liver injury through elevated liver enzymes. Some patients also suffer from "long COVID." This involves persistent symptoms like fatigue and cognitive issues for months or years. In rare cases, children may develop a serious condition called paediatric multisystem inflammatory syndrome.

Scientists track the virus by studying its many different variants.

Coronavirus virion structure
Coronavirus virion structure

These variants are grouped into lineages or clades. The WHO uses Greek letters like Alpha, Delta, and Omicron to name them. This makes it easier for non-scientific audiences to discuss them. Different tools like GISAID and Nextstrain help researchers track these genetic changes. Some variants, like the Omicron variant, have spread to many countries very quickly. Monitoring these changes is essential for developing effective vaccines and treatments.

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🖼️ Images & Media (24)
File:Fimmu-11-01648-g001.jpg
Fimmu-11-01648-g001.jpg
File:Transmission of COVID-19.jpg
Transmission of COVID-19.jpg
File:Coronavirus virion structure.svg
Coronavirus virion structure.svg
File:Fpubh-08-00383-g003.jpg
Fpubh-08-00383-g003.jpg
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File:Fimmu-11-579250-g003.jpg
Fimmu-11-579250-g003.jpg
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Fpubh-08-00383-g004.jpg
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File:Infektionsschutzzentrum im Rautenstrauch-Joest-Museum, Köln-6313 (cropped).jpg
Infektionsschutzzentrum im...
File:COVID19CTPneumonia.jpg
COVID19CTPneumonia.jpg
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File:COVID-19 Pneumonie - 82m Roe Thorax ap - 001.jpg
COVID-19 Pneumonie - 82m Roe Thorax ap - 001.jpg

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