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Virus

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A virus is a submicroscopic infectious agent that can only replicate inside the living cells of an organism.

Phage
Phage

They are incredibly widespread, infecting all life forms, including animals, plants, and microorganisms like bacteria and archaea. Because they exist in almost every ecosystem on Earth, they are considered the most numerous type of biological entity. The study of these agents is called virology, which is a specialized branch of microbiology.

Viral infections and involved species
Viral infections and involved species

Scientists have described more than 16,000 specific virus species, though millions more likely exist.

When a virus is not inside a host, it exists as an independent particle called a virion.

Phage injecting its genome into bacteria
Phage injecting its genome into bacteria

A virion typically consists of three main parts. First, it contains genetic material in the form of long DNA or RNA molecules. These molecules encode the instructions for the virus's protein structures. Second, the genetic material is protected by a protein coat known as a capsid. In some cases, a third layer called an envelope, made of lipids, surrounds the capsid.

VirusBaltimoreClassification
VirusBaltimoreClassification

These particles come in many shapes, ranging from simple helical forms to complex icosahedral structures.

To reproduce, a virus must undergo a process of hijacking a host cell. Once the virus enters a host, it often forces that cell to rapidly produce thousands of new copies of the original virus.

HepC replication
HepC replication

The variety of cells a virus can infect is known as its host range. Some viruses have a narrow range, meaning they only infect a few specific species. Others have a broad host range and can infect many different types of organisms. In animals, these infections usually trigger an immune response to eliminate the virus. However, some viruses, such as HIV or those causing hepatitis, can evade the immune system to create chronic infections.

Viruses use many different pathways to spread between hosts. Some are transmitted by vectors, which are disease-bearing organisms like insects. For example, aphids can carry viruses between plants, while blood-sucking insects can carry viruses in animals. Other viruses spread through the air via coughing or sneezing, such as influenza, measles, and SARS-CoV-2.

Influenza virus research
Influenza virus research

Some viruses, like norovirus, are transmitted through the faecal–oral route via contaminated food or water. For norovirus, the infectious dose is remarkably small, requiring fewer than 100 particles to cause infection in humans.

Rotavirus with antibody
Rotavirus with antibody

Others, like HIV, are transmitted through sexual contact or exposure to infected blood.

Our understanding of viruses grew through key scientific discoveries. In 1892, Dmitri Ivanovsky used filters to show that sap from diseased tobacco plants remained infectious even after bacteria were removed.

Pepper mild mottle virus
Pepper mild mottle virus

In 1898, Martinus Beijerinck identified the tobacco mosaic virus, marking the beginning of virology. Later, Wendell Meredith Stanley proved that viruses were particles rather than fluids. The invention of the electron microscope in 1931 was a major turning point, as it allowed scientists to finally visualize these complex structures.

Reconstructed Spanish Flu Virus
Reconstructed Spanish Flu Virus

Before this, most viruses were too small to be seen with an optical microscope.

There is an ongoing scientific debate regarding whether viruses are truly alive. They are often called "organisms at the edge of life" because they possess certain biological traits. They carry genetic material, they evolve through natural selection, and they reproduce by self-assembly. However, they lack a cellular structure and do not have their own metabolism to produce energy. Unlike most living things that use cell division, viruses rely entirely on the host's machinery. Some scientists propose the virocell model, suggesting the infected cell itself is the living form of the virus.

Because viruses do not leave fossils, their exact origins remain a mystery. Scientists use molecular techniques to explore three main hypotheses. The regressive hypothesis suggests viruses were once small cells that lost genes as they became parasites. The cellular origin hypothesis proposes they escaped from the genes of larger organisms, perhaps from pieces of DNA called plasmids or transposons. The co-evolution hypothesis suggests they evolved alongside the very first cells on Earth.

Viruses-10-00497-g003
Viruses-10-00497-g003

It is likely that viruses have arisen many different times through various mechanisms throughout history.

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🖼️ Images & Media (11)
File:Viruses-10-00497-g003.png
Viruses-10-00497-g003.png
File:HepC replication.png
HepC replication.png
File:Phage injecting its genome into bacteria.svg
Phage injecting its genome into bacteria.svg
File:VirusBaltimoreClassification.svg
VirusBaltimoreClassification.svg
File:Viral infections and involved species.svg
Viral infections and involved species.svg
File:Reconstructed Spanish Flu Virus.jpg
Reconstructed Spanish Flu Virus.jpg
File:Rotavirus with antibody.jpg
Rotavirus with antibody.jpg
File:Guanosine aciclovir comparison.svg
Guanosine aciclovir comparison.svg
File:Pepper mild mottle virus.png
Pepper mild mottle virus.png
File:Phage.jpg
Phage.jpg
File:Influenza virus research.jpg
Influenza virus research.jpg
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