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Introduction to viruses

life science Maturity 11-13 Next article →

A virus is a tiny infectious agent that reproduces only inside the cells of a living host. Unlike most living organisms, viruses do not possess cells that can divide on their own. Instead, a virus must enter a host cell to function. Once inside, the host cell is forced to rapidly produce thousands of identical copies of the original virus. These new viruses are assembled directly within the infected host cell.

Basic Scheme of Virus en
Basic Scheme of Virus en

While they are much simpler than cells, viruses contain genes. These genes allow them to mutate and evolve over time. Scientists have described over 4,800 species of viruses in detail, even though millions more exist in the environment.

Every virus is built from two or three primary components. All viruses contain genes, which carry the biological instructions for the virus. These genes are constructed from either DNA (deoxyribonucleic acid) or RNA (ribonucleic acid), but never both. To protect this genetic material, the virus uses a protein coat called a capsid. This capsid is made of many smaller, identical protein units called capsomers.

Capsids
Capsids

Some viruses also possess a viral envelope. This is a bubble of fat-like substance, or lipid, that surrounds the protein coat. The envelope helps the virus use specific receptors to enter new host cells. However, this layer also makes the virus vulnerable to soap and alcohol.

Viruses vary greatly in their physical structure and size. Their shapes can be simple, such as helical or icosahedral (20-faced), or they can be quite complex.

Capsids
Capsids

In terms of size, viruses typically range from 20 to 300 nanometres. To visualize this, it would take between 33,000 and 500,000 viruses laid end to end to stretch just one centimetre. They are much smaller than bacteria, which are usually around 1,000 nanometres in diameter. However, some "giant" viruses, like megaviruses, were discovered in 2003 and 2013. These can reach 1,000 nanometres, making them ten times wider than the influenza virus.

Virus size
Virus size

The way viruses spread depends on their specific type and host. Many viruses are very specific about which species or tissues they attack. Plant viruses are often spread by insects or other organisms known as vectors. In humans, some viruses spread through exposure to infected bodily fluids. Influenza is spread through the air via moisture droplets from coughing or sneezing. Others, like norovirus, use the faecal–oral route through contaminated food or water. Some viruses, such as dengue, are carried by blood-sucking insects, while HIV is transmitted through bodily fluids during sex.

Viruses can change through a process called mutation. This is especially common in viruses made of RNA. Because the enzymes that copy RNA, called RNA polymerase, are error-prone, these viruses mutate rapidly. This can lead to new strains that the host's immune system does not recognize. Major changes can cause pandemics, such as the 2009 swine influenza that spread to most countries. Often, these mutations occur when a virus first infects an animal host before moving to humans. These are known as zoonotic diseases, such as coronaviruses in bats or influenza in pigs and birds.

HIV-budding-Color cropped
HIV-budding-Color cropped

The history of virology is a journey of discovery through better technology. In 1884, Charles Chamberland invented a filter with pores smaller than bacteria. In the early 1890s, Dmitri Ivanovsky used this to show that extracts from infected tobacco plants remained infectious after filtration. Martinus Beijerinck later observed that these agents only multiplied in dividing cells, calling them a "contagious living fluid." The invention of the electron microscope in 1931 finally allowed scientists to see actual images of viruses. In 1935, Wendell Meredith Stanley found that the tobacco mosaic virus was made of protein. Later, Rosalind Franklin used X-ray crystallography in 1955 to confirm the spiral structure of viral proteins and RNA.

Cell with Virus
Cell with Virus

Understanding viruses is vital for human health and medicine. While viral infections can cause disease, the immune system often eliminates them in healthy hosts. This can even provide lifetime immunity. It is important to note that antibiotics, which fight bacteria, have no impact on viruses. Instead, doctors use antiviral drugs to treat serious infections. Vaccines are also used to prevent many infections by preparing the immune system in advance. By studying how viruses interact with cells, scientists continue to develop new ways to manage these tiny but powerful agents.

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🖼️ Images & Media (14)
File:Coronavirus. SARS-CoV-2.png
Coronavirus. SARS-CoV-2.png
File:HIV-budding-Color cropped.jpg
HIV-budding-Color cropped.jpg
File:Basic Scheme of Virus en.svg
Basic Scheme of Virus en.svg
File:Capsids.jpg
Capsids.jpg
File:Virus size.png
Virus size.png
File:Cell with Virus.png
Cell with Virus.png
File:HepC replication.png
HepC replication.png
File:SIV primates.jpg
SIV primates.jpg
File:Orgin and evolution of SARS.jpg
Orgin and evolution of SARS.jpg
File:Pepper mild mottle virus.png
Pepper mild mottle virus.png
File:PhageExterior.svg
PhageExterior.svg
File:Rotavirus with antibody.jpg
Rotavirus with antibody.jpg

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