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Saliva

life science Maturity 11-13 Next article →

Saliva is an extracellular fluid produced by the salivary glands in the mouth.

Saliva Baby
Saliva Baby

It is a vital substance for maintaining oral and systemic health. In humans, saliva is approximately 99.5% water. The remaining portion contains electrolytes, mucus, white blood cells, and epithelial cells. It also contains various enzymes and antimicrobial agents. These components work together to protect the body and assist in digestion. Because it contains many biological markers, doctors can use it to diagnose diseases noninvasively.

The production of saliva involves a complex biological mechanism. It is stimulated by both the sympathetic and parasympathetic nervous systems. The parasympathetic nervous system facilitates digestion by releasing acetylcholine (ACh). This chemical binds to specific muscarinic receptors on the salivary acinar cells. This process increases the concentration of intracellular calcium ions. Higher calcium levels cause vesicles within the cells to fuse with the cell membrane. This fusion results in the secretion of saliva into the mouth. Additionally, the release of kallikrein causes vasodilation in the salivary glands. This increases blood flow, allowing the glands to produce even more fluid.

Saliva performs several distinct functions, primarily digestion and protection. As a lubricant, it coats the oral mucosa to prevent trauma during eating or speaking. It also helps create a food bolus, which is a soft mass of food. This bolus can then pass easily into the esophagus. Saliva also acts as a buffer to control the acidity of the mouth. It uses bicarbonate and phosphate to maintain a pH between 6.2 and 7.4. This prevents the minerals in dental tissues from dissolving. Furthermore, saliva aids the sense of taste by acting as a liquid medium. It carries chemicals to the taste receptor cells on the tongue.

Digestion begins in the mouth through the action of specific enzymes. One key enzyme is alpha-amylase, also known as ptyalin. It is secreted by the parotid and submandibular glands. This enzyme breaks down dietary starches into simpler sugars like maltose. About 30% of starch digestion occurs within the mouth cavity. Another enzyme, lingual lipase, is secreted by the sublingual gland. This enzyme begins the process of fat digestion. It is not fully activated until it reaches the acidic environment of the stomach. This is especially important for newborn infants whose pancreatic lipase is still developing.

Protection against infection is another critical role of saliva. It contains many antimicrobial enzymes and compounds. These include lysozyme, lactoferrin, and secretory immunoglobulin A. These substances work to kill bacteria and limit the growth of pathogens. Proline-rich proteins also assist in microbe killing and enamel formation. Saliva can contain as many as 8 million human cells and 500 million bacterial cells per milliliter. It also contains epidermal growth factor (EGF). This protein promotes cellular healing and protects the mucosa from gastric acid and bile acids.

Humans produce a significant amount of saliva every day. A healthy person is estimated to produce about 1,500 mL of saliva daily. The submandibular gland is the most productive, contributing 70% to 75% of this total. The parotid gland contributes about 20% to 25%. The remaining amounts come from other smaller salivary glands. Production levels change depending on activity, as the amount of saliva drops significantly during sleep. Some people suffer from xerostomia, which is a condition of reduced saliva. This can lead to mouth soreness and difficulty swallowing dry foods.

Beyond humans, many animals use saliva for specialized survival tasks. Certain swifts in the genus Aerodramus use sticky saliva to glue their nests together. These nests are sometimes used by humans to make bird's nest soup. Venomous animals, such as cobras and vipers, use venomous saliva to hunt prey. Some caterpillars use modified glands to store proteins for making silk fiber. Even the act of spitting has different meanings across the world. In Singapore, spitting can result in a fine of up to SGD$2,000. In other cultures, it may be used as a defensive maneuver by animals like camels.

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