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Rosalind Franklin

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Rosalind Elsie Franklin was a highly skilled English chemist and X-ray crystallographer.

ROSALIND FRANKLIN 1920-1958 Pioneer of the study of molecular structures including DNA lived here 1951-1958
ROSALIND FRANKLIN 1920-1958 Pioneer of the study of molecular structures including DNA lived here 1951-1958

X-ray crystallography is a scientific technique used to determine the atomic and molecular structure of a crystal. By directing X-rays at a sample, scientists can observe the resulting diffraction patterns. These patterns reveal how atoms are arranged in space. Franklin’s expertise in this field was essential for understanding the molecular structures of DNA, RNA, viruses, coal, and graphite. While her research on coal and viruses was respected during her lifetime, her role in the discovery of the DNA structure was largely unacknowledged while she lived. Because of this, she has been called many names, such as the "forgotten heroine" or the "dark lady of DNA."

Franklin’s scientific method relied on observing how different materials reacted to physical properties. In her early career, she studied the porosity of coal. Porosity refers to the tiny spaces or holes within a material. Franklin used helium to measure the density of these spaces. She discovered that substances are expelled from coal in order of their molecular size as the temperature increases. This discovery helped scientists classify different types of coal. It also allowed them to predict how coal would perform as fuel. This work was vital for creating wartime devices like gas masks. This research formed the basis of her PhD thesis, which she earned from the University of Cambridge in 1945.

After her work in England, Franklin moved to Paris in 1947 to work with Jacques Mering.

Mering was an expert in applying X-ray diffraction to amorphous substances. Amorphous substances are materials that do not have a regular, repeating crystal structure. This was a significant challenge because most X-ray work had focused on regular crystals. Franklin applied these methods to study how carbon changes when it is converted to graphite. She successfully identified two types of carbon: graphitising and non-graphitising. Her findings in Paris became a core part of the study of the physics and chemistry of carbon.

In 1951, Franklin began a new chapter as a research associate at King's College London.

Blue plaque on The Eagle - geograph.org.uk - 6004523
Blue plaque on The Eagle - geograph.org.uk - 6004523

She worked in the Medical Research Council's Biophysics Unit under the direction of John Randall. Although she was originally hired to study proteins and lipids, Randall redirected her focus to DNA fibers. This shift led to some of her most famous work. While at King's College, Franklin discovered key properties of DNA. These properties were necessary to describe the double helix structure. Her student, Raymond Gosling, captured a famous X-ray diffraction image known as Photo 51.

In memoriam card Wellcome L0043312 (cropped)
In memoriam card Wellcome L0043312 (cropped)

This image was critical to the discovery of the DNA structure. However, the image was shown to James Watson by Maurice Wilkins without Franklin's permission.

Due to disagreements with her director, John Randall, and her colleague, Maurice Wilkins, Franklin moved to Birkbeck College in 1953.

TMV virus under magnification
TMV virus under magnification

At Birkbeck, she worked under John Desmond Bernal. She led pioneering research into the molecular structures of viruses. One of her major focuses was the tobacco mosaic virus. Her work helped scientists understand how these viruses are built at a molecular level. This research was highly advanced for the time and laid the groundwork for future studies in virology.

Franklin’s life was marked by both great achievement and early loss. She was born on July 25, 1920, into an influential British Jewish family in London.

Rue Rosalind Franklin
Rue Rosalind Franklin

She was a brilliant student who excelled in science, Latin, and several languages. Despite her scientific success, she faced professional difficulties and interpersonal conflicts. In 1958, at the age of 37, Franklin died of ovarian cancer. This occurred just one day before she was scheduled to present her work on the tobacco mosaic virus at an international fair in Brussels. Her death came before she could receive the widespread recognition her work deserved.

The impact of Franklin's work is seen in the highest honors of science. In 1962, Francis Crick, James Watson, and Maurice Wilkins shared the Nobel Prize in Physiology or Medicine for the discovery of the DNA double helix. James Watson later remarked that if Franklin had not died, she likely would have been awarded a Nobel Prize in Chemistry. Although she did not live to see the full impact of her DNA research, her legacy continued through her colleagues. Her team member at Birkbeck, Aaron Klug, continued her research on viruses and won the Nobel Prize in Chemistry in 1982.

Rosalind Franklin University of Medicine and Science, (cropped)
Rosalind Franklin University of Medicine and Science, (cropped)

Today, her contributions are recognized as foundational to the field of molecular biology.

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🖼️ Images & Media (8)
File:In memoriam card Wellcome L0043312 (cropped).jpg
In memoriam card Wellcome L0043312 (cropped).jpg
File:TMV virus under magnification.jpg
TMV virus under magnification.jpg
File:Blue plaque on The Eagle - geograph.org.uk - 6004523.jpg
Blue plaque on The Eagle -...
File:Franklin-Wilkins Building King's College London.jpg
Franklin-Wilkins Building King's College...
File:ROSALIND FRANKLIN 1920-1958 Pioneer of the study of molecular structures including DNA lived here 1951-1958.jpg
ROSALIND FRANKLIN 1920-1958 Pioneer of...
File:Rosalind Franklin University of Medicine and Science, (cropped).jpg
Rosalind Franklin University of Medicine...
File:Rue Rosalind Franklin.svg
Rue Rosalind Franklin.svg
File:רחל פרנקלין שלט רחוב.jpg
רחל פרנקלין שלט רחוב.jpg
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