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Robert Gallo

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Robert Charles Gallo is a prominent American biomedical researcher. He is best known for identifying the human immunodeficiency virus (HIV) as the cause of acquired immune deficiency syndrome (AIDS). Gallo also played a vital role in developing the HIV blood test. His work has significantly advanced the study of viruses and the human immune system. Currently, he serves as the James P. Cullison Professor of Medicine at the University of South Florida. He also directs the USF Health Institute for Translational Virology and Innovation.

Gallo's journey into science was driven by a personal loss. His sister died from leukemia, a cancer of the blood. This event led him to dedicate much of his early research to the disease. He earned a B.S. in biology from Providence College in 1959. He later received his M.D. from Jefferson Medical College in 1963. After his medical residency in Chicago, he joined the National Cancer Institute. He spent 30 years there, primarily leading the Laboratory of Tumor Cell Biology.

A major turning point occurred in 1976 through the study of cell growth. Gallo asked a post-doctoral fellow, Doris Morgan, to examine culture fluid from activated lymphocytes. She successfully grew T lymphocytes, which are essential immune cells. Gallo, Morgan, and Frank Ruscetti identified a growth factor in this process. Originally called T-cell growth factor (TCGF), it was renamed interleukin-2 (IL-2) in 1978. This discovery was revolutionary because it allowed scientists to grow T cells in a lab. Previously, these cells were considered "dead end" cells that could not be cultivated.

The ability to grow T cells opened doors to studying human retroviruses. A retrovirus is a type of virus that inserts its genetic material into a host cell. In Gallo's lab, researcher Bernard Poiesz helped isolate the first human retrovirus, known as HTLV. This virus was later linked to certain types of leukemia and lymphomas. For this pioneering work, Gallo received the Lasker Award in 1982. He later became the only person to receive this prestigious award twice.

In 1984, Gallo and his collaborators published findings in the journal Science. They demonstrated that a retrovirus they called HTLV-III was the cause of AIDS. This followed a 1983 report from a French team led by Luc Montagnier. The French team had isolated a virus they called LAV. There was significant controversy regarding which team discovered the virus first. Investigations later showed that a sample from the French lab had contaminated a sample in Gallo's lab. The two groups eventually agreed to be recognized as co-discoverers in 1987.

Beyond discovery, Gallo has focused on treating and preventing viral infections. In 1995, he and colleagues discovered that chemokines can inhibit HIV. Chemokines are naturally occurring compounds that act as signals in the immune system. This discovery led to the development of entry inhibitors, a class of drugs used to treat HIV. In 1996, he co-founded the Institute of Human Virology (IHV). The IHV provides clinical care to thousands of patients in Baltimore, Africa, and the Caribbean.

Gallo's research continues to receive significant support for vaccine development. In 2007, the Bill and Melinda Gates Foundation provided a $15 million grant for HIV vaccine research. In 2011, his team received an additional $23.4 million from various funding sources. These funds support the development of a promising HIV/AIDS preventive vaccine candidate. Throughout his career, Gallo has published over 1,300 scientific papers. From 1980 to 1990, he was the most cited scientist in the world. His work remains a cornerstone of modern infectious disease research.

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