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Osteoporosis

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Osteoporosis is a systemic skeletal disorder that affects the entire body. The name comes from Greek terms meaning "porous bones." This condition is characterized by low bone mass, also known as osteopenia. It also involves the deterioration of the micro-architecture of bone tissue. This structural decay makes the bone more porous. As a result, the risk of fractures increases significantly.

Blausen 0686 Osteoporosis 01
Blausen 0686 Osteoporosis 01

Our bones are not static structures. They undergo a continuous process called remodeling. This process involves two specific types of cells working together. First, osteoclasts resorb or remove old bone tissue. Next, osteoblasts synthesize or build new bone. In a healthy system, these two processes stay in balance. However, with osteoporosis, the rate of resorption exceeds the rate of formation. This imbalance causes bones to lose density and become fragile.

625 Calcium Homeostasis
625 Calcium Homeostasis

There are many factors that contribute to this bone loss. Hormonal changes play a major role in the process. For women, bone loss increases after menopause due to lower estrogen levels. In men, bone loss can increase after andropause due to lower testosterone. Certain medical conditions also increase risk. These include hyperparathyroidism, hyperthyroidism, and kidney disease. Additionally, some medications can speed up bone loss. These include glucocorticosteroids, certain antiseizure medications, and chemotherapy.

Osteoporosis Locations
Osteoporosis Locations

Lifestyle choices also impact bone health. Smoking and a sedentary lifestyle are recognized as major risk factors. Alcohol consumption of more than three units per day can increase risk. A lack of physical activity can also lead to bone loss because remodeling responds to physical stress. Weight-bearing exercise is helpful for building bone strength. Nutrition is another critical factor. Low levels of calcium, magnesium, or vitamin D can weaken the skeleton. Vitamin D is especially important for maintaining bone mineral density.

615 Age and Bone Mass
615 Age and Bone Mass

Because osteoporosis often has no symptoms, it is a silent condition. People may not know they have it until a bone breaks. These are called fragility fractures. They occur during minor stress, such as coughing, bending, or a small fall. Common fracture sites include the wrist, spine, shoulder, and hip.

L1 2 vertebral fracture
L1 2 vertebral fracture

A vertebral collapse, or compression fracture, can cause sudden back pain. This may even lead to a stooped posture and loss of height. Hip fractures are particularly serious and often require prompt surgery.

Hip fracture incidence world map
Hip fracture incidence world map

Osteoporosis is very common among the elderly. About 15% of Caucasians in their 50s are affected. This number rises to 70% for those over age 80. In the United States, about 8 million women and 1 to 2 million men had the condition in 2010. In the European Union, roughly 22 million women and 5.5 million men were affected in 2010. Doctors define osteoporosis using a specific measurement. They look for a bone density that is 2.5 standard deviations below that of a young adult. This is typically measured using dual-energy X-ray absorptiometry, or DXA.

Menopause - Osteoporosis -- Smart-Servier (cropped)
Menopause - Osteoporosis -- Smart-Servier (cropped)

Understanding these risks helps in preventing future breaks. Doctors use fracture risk calculators like FRAX to assess danger. These tools look at age, gender, smoking, and bone density. Prevention includes maintaining a proper diet during childhood to reach peak bone mass. For adults, exercise and fall prevention are vital. Some people use bisphosphonate medications to decrease the risk of future breaks. These medications are most useful for people who have already experienced a fracture. Managing these factors can help improve quality of life and reduce the risk of disability.

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🖼️ Images & Media (7)
File:Blausen 0686 Osteoporosis 01.png
Blausen 0686 Osteoporosis 01.png
File:Menopause - Osteoporosis -- Smart-Servier (cropped).jpg
Menopause - Osteoporosis -- Smart-Servier...
File:615 Age and Bone Mass.jpg
615 Age and Bone Mass.jpg
File:625 Calcium Homeostasis.jpg
625 Calcium Homeostasis.jpg
File:Osteoporosis Locations.png
Osteoporosis Locations.png
File:L1 2 vertebral fracture.jpg
L1 2 vertebral fracture.jpg
File:Hip fracture incidence world map.svg
Hip fracture incidence world map.svg
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