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June Almeida

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June Almeida was a pioneering Scottish virologist who revolutionized how we see the microscopic world. A virologist is a scientist who studies viruses, which are tiny particles that can cause disease. Before her work, scientists struggled to observe these particles clearly. Almeida used electron microscopy to bridge this gap. Electron microscopy uses a beam of electrons rather than light to create highly detailed images. Her innovations allowed researchers to identify new viruses and understand their complex structures. This work laid the foundation for modern viral diagnosis and research.

Almeida developed several critical techniques to improve viral imaging. One method she used was negative staining. In this process, a substance is applied to a sample to surround the particles. This creates a dark background that makes the lighter virus particles stand out clearly. She also pioneered immune electron microscopy, or IEM. This technique uses antibodies to target and aggregate viruses. When antibodies bind to the viruses, they cause the particles to clump together. These clumps are much easier to detect and study under an electron microscope. These refinements changed virology by making it possible to see viruses in clinical samples.

In 1966, Almeida made her most famous discovery while working at St Thomas's Hospital Medical School. She was collaborating with David Tyrrell, who was researching the common cold. Tyrrell's team was trying to find a specific respiratory virus known as B814. At the time, many scientists believed viruses had to be highly purified to be seen. Almeida used her new techniques to examine samples from organ cultures. She successfully identified virus particles in the B814 samples. She noticed these particles had a distinct shape. They appeared to be surrounded by a fringe or a "halo."

This unique appearance led to a new scientific name. The word for crown in Latin is "corona." Because the viruses looked like they were wearing crowns, Tyrrell suggested the name coronavirus. Almeida and Tyrrell described these particles as being between 800 and 1200 Å in size. They also noted a distinct fringe that was about 200 Å long. This group of viruses was previously uncharacterized in humans. The coronavirus family is significant because it includes viruses like SARS and SARS-CoV2. The latter is the virus that causes the COVID-19 pandemic.

Almeida's career spanned several prestigious institutions and countries. She was born in Glasgow, Scotland, in 1930. After studying at Whitehill Secondary School, she worked as a technician at Glasgow Royal Infirmary. She later moved to Canada, where she spent ten years at the Ontario Cancer Institute. There, she published important research on virus-like particles in cancer patients' blood. In 1964, she was recruited to London to join the research team at St Thomas's. By 1967, she earned her Doctor of Science based on her extensive research. She later worked at the Royal Postgraduate Medical School and the Wellcome Institute.

Her research contributed to the understanding of many different diseases. In 1971, using her IEM technique, she discovered that the hepatitis B virus has two parts. It consists of an outer coat and a small inner component. She also produced the first visualizations of the rubella virus in 1967. Later in her career, she helped produce micrographs of the HIV virus. Her training and methods also helped others. For example, Albert Kapikian used her IEM techniques to identify the Norwalk virus. Her work has been vital in the study of gastroenteritis and infectious hepatitis.

Today, the legacy of June Almeida is more relevant than ever. During the COVID-19 pandemic, scientists relied on the principles of virology she helped establish. Experts have noted that her techniques aided the early identification of the SARS-CoV2 virus. Her original notebooks are now part of exhibitions, such as "Injecting Hope" at the National Museum of Scotland. In 2020, a new COVID-19 testing laboratory at Guy's Hospital was named in her honor. Her ability to see the invisible continues to protect global health.

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