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Henrietta Lacks

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Henrietta Lacks was an African-American woman whose biological material changed the course of modern medicine.

Henrietta Lacks statue, Bristol, RHS
Henrietta Lacks statue, Bristol, RHS

Her cells became the source of the HeLa cell line. This was the first immortalized human cell line ever created. An immortalized cell line is a group of cells that can reproduce indefinitely under specific conditions. Today, HeLa cells remain one of the most important tools in medical research. They provide a constant source of data for scientists studying human biology and disease.

In 1951, Lacks sought treatment at the Johns Hopkins Hospital in Baltimore, Maryland. She had been feeling a "knot" in her womb. Doctors performed a biopsy, which is a procedure to take a sample of tissue, on a mass found on her cervix. She was diagnosed with a malignant epidermoid carcinoma of the cervix. In 1970, physicians discovered she actually had an adenocarcinoma, though the treatment would not have differed. During her treatment, researchers took two samples from her cervix without her knowledge or permission. One sample contained healthy tissue, and the other contained cancerous cells. These samples were provided to George Otto Gey, a cancer researcher.

George Gey observed that these specific cells behaved very differently from others. Usually, human cells cultured in a laboratory survive for only a few days. However, Lacks's cells reproduced at an extremely high rate. They could be kept alive in a laboratory setting for a very long time. Because they could divide repeatedly without dying, they were called "immortal." Gey used the roller-tube technique to culture the cells. He isolated one specific cell and repeatedly divided it. He named the line "HeLa" by using the first two letters of her first and last names.

Cell culture (HeLa cells) (261 18) Cell culture (HeLa cells) - metaphase, telophase
Cell culture (HeLa cells) (261 18) Cell culture (HeLa cells) - metaphase, telophase

The ability to mass-produce these cells led to many scientific breakthroughs. In 1954, Jonas Salk used HeLa cells to help develop the polio vaccine. To test this vaccine, scientists used the first-ever cell production factory. In 1955, HeLa cells became the first human cells to be successfully cloned. Scientists have also used them to study AIDS, radiation, and toxic substances. They have even been used to test how humans react to products like glue, tape, and cosmetics. There are now nearly 11,000 patents that involve HeLa cells.

Lacks's life began on August 1, 1920, in Roanoke, Virginia. She was born Loretta Pleasant to Eliza and John Pleasant. Her early life involved working as a tobacco farmer in Clover, Virginia. She had to leave school in the sixth grade to help support her family. Later, she married David "Day" Lacks in 1941. The couple moved to Turner Station, Maryland, to work near Baltimore. They had several children together, including David Jr., Deborah, and Joseph. Henrietta died on October 4, 1951, at the age of 31. An autopsy showed the cancer had metastasized, or spread, throughout her entire body.

Lacks Town Road; Clover, VA; 2013-07-14
Lacks Town Road; Clover, VA; 2013-07-14

The history of HeLa also involves significant ethical questions. At the time the cells were taken, doctors did not ask for consent. This was common practice in 1951, but it caused later problems. The Lacks family did not learn about the cell line until 1975. This happened through a conversation at a dinner party. Before this, the family had not even discussed Henrietta's illness with one another. In the 1980s, medical records of the family were published without their permission. In 2013, researchers published the DNA sequence of a HeLa strain. This caused concern for the family regarding their genetic privacy.

Henrietta Lacks historical marker; Clover, VA; 2013-07-14
Henrietta Lacks historical marker; Clover, VA; 2013-07-14

Today, the story of Henrietta Lacks connects biology to the study of patient rights. The use of her cells for commercial purposes continues to raise questions. In 1990, a court case called Moore v. Regents of the University of California ruled that discarded cells are not the property of the patient. This means cells can be used for profit by others. The Lacks family continues to navigate the impact of her genetic information being public. Henrietta Lacks is now remembered through historical markers and even a dedicated park.

Henrietta Lacks Educational Park
Henrietta Lacks Educational Park

Her legacy lives on in every laboratory that uses HeLa cells.

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🖼️ Images & Media (5)
File:Lacks Town Road; Clover, VA; 2013-07-14.JPG
Lacks Town Road; Clover, VA; 2013-07-14.JPG
File:Cell culture (HeLa cells) (261 18) Cell culture (HeLa cells) - metaphase, telophase.jpg
Cell culture (HeLa cells) (261 18) Cell...
File:Henrietta Lacks historical marker; Clover, VA; 2013-07-14.JPG
Henrietta Lacks historical marker;...
File:Henrietta Lacks Educational Park.jpg
Henrietta Lacks Educational Park.jpg
File:Henrietta Lacks statue, Bristol, RHS.jpg
Henrietta Lacks statue, Bristol, RHS.jpg
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