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Gastrointestinal tract

life science Maturity 11-13 Next article →

The gastrointestinal tract, often called the GI tract or alimentary canal, is a continuous passageway. It runs from the mouth to the anus. This system is one of the largest in the human body. Its primary purpose is to digest food to extract nutrients and absorb energy. Once nutrients are removed, the remaining waste is expelled as feces.

Digestive system simplified
Digestive system simplified

The tract is divided into the upper and lower gastrointestinal tracts. The upper tract includes the mouth, pharynx, esophagus, stomach, and the duodenum. The duodenum is the first part of the small intestine. A thin muscle called the suspensory muscle of the duodenum marks the boundary. This muscle connects the duodenum to the jejunum, which is the next section. The lower tract consists of the rest of the small intestine and the entire large intestine. This division is important for clinicians when they identify the origin of gastrointestinal bleeding.

Layers of the GI Tract english
Layers of the GI Tract english

The small intestine is a long, tubular structure measuring about 6 to 7 meters in length. It is divided into three parts: the duodenum, the jejunum, and the ileum. The duodenum is roughly 20 to 25 cm long. It receives chyme, which is partially digested food, from the stomach. In this section, pancreatic juice and bile from the gallbladder enter the tract. Enzymes break down proteins, while bile emulsifies fats into micelles. Brunner's glands in the duodenum produce an alkaline mucus. This secretion, along with bicarbonate from the pancreas, neutralizes stomach acids. The jejunum is the midsection where sugars, amino acids, and fatty acids are absorbed. The ileum is the final 3-meter section. It primarily absorbs vitamin B12 and bile acids.

The large intestine is much shorter, measuring about 1.5 meters. It forms an arch starting at the cecum and ending at the rectum. The colon is the longest part of this system. Its main job is to absorb water and salts. The large intestine includes the cecum, the appendix, and several parts of the colon. These parts are the ascending, transverse, descending, and sigmoid colons. The transverse colon runs across the abdomen. The descending colon moves down the left side. Finally, the waste moves through the rectum and the anal canal.

Microbiome
Microbiome

The structure of the gut wall consists of four concentric layers. The innermost layer is the mucosa, which surrounds the lumen, or open space. The mucosa contains the epithelium, which handles absorption and secretion. Below this is the submucosa, a layer of connective tissue containing blood vessels and nerves. The third layer is the muscularis externa, or muscular layer. This layer contains an inner circular layer and an outer longitudinal layer. The circular layer prevents food from moving backward. The longitudinal layer helps shorten the tract. In the stomach, a third oblique muscle layer helps grind food. Between these muscle layers is the myenteric plexus, which helps control movement.

Movement through the tract happens via peristalsis. This is a series of coordinated muscle contractions that propel food forward. These contractions are managed by the enteric nervous system, which is a self-contained nervous system within the gut. Specialized pacemaker cells called myenteric interstitial cells of Cajal initiate this activity. The gut also contains a massive collection of microorganisms called the microbiota. This includes around 4,000 different strains of bacteria, archaea, viruses, and eukaryotes. These organisms play vital roles in metabolism and immune health.

Layers of the GI Tract english
Layers of the GI Tract english

The development of the gut begins in the human embryo. Around the sixteenth day, the embryo folds to create the primitive gut. This structure is derived from the endoderm, a primary layer of cells. The primitive gut eventually patterns into three segments: the foregut, midgut, and hindgut. The foregut gives rise to the esophagus, stomach, and the first parts of the duodenum. The midgut forms the lower duodenum, the jejunum, ileum, cecum, and part of the colon. The hindgut forms the final third of the transverse colon and the descending colon. This embryological origin determines the blood supply for each section through specific arteries.

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File:Digestive system simplified.svg
Digestive system simplified.svg
File:Layers of the GI Tract english.svg
Layers of the GI Tract english.svg
File:Microbiome.jpg
Microbiome.jpg
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