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Gallstone

life science Maturity 11-13 Next article →

Gallstones are solid objects that form inside the gallbladder, a small organ that stores bile. Bile is a fluid that helps the body digest food. When stones form within the gallbladder, the condition is called cholelithiasis. If a stone moves out of the gallbladder and into the bile ducts, it is called choledocholithiasis.

Human gallstones 2015 G1
Human gallstones 2015 G1

Many people live with these stones without knowing it. Between 60% and 80% of people with gallstones are asymptomatic, meaning they show no symptoms. These are often called "silent stones." They can remain in the body for many years without causing any medical trouble.

To understand how stones form, we must look at the chemistry of bile. Bile is composed of several substances, including cholesterol, bile salts, and bilirubin. Stones typically develop when the balance of these components changes. For example, cholesterol stones form when the bile contains too much cholesterol and not enough bile salts.

Types of Gallstones
Types of Gallstones

Another factor is how the gallbladder moves, or its motility. If the gallbladder does not contract often or effectively, the bile can become overconcentrated. This process allows the components to crystallize into solid stones. Certain proteins in the liver and bile can also encourage this crystallization process.

Scientists classify gallstones into different types based on what they are made of. Cholesterol stones are the most common type. They can vary in color from light yellow to dark green, brown, or even chalk white. These stones are usually oval and can be between 2 and 3 cm long.

Gallstone µCT
Gallstone µCT

Pigment stones are another major category. These are formed primarily from bilirubin. Pigment stones are more frequently seen in the developing world. Other stones can be "mixed," meaning they contain a combination of different materials. The specific composition of a stone is often influenced by a person's age, diet, and ethnicity.

When gallstones cause problems, the most common symptom is biliary colic. This is often called a "gallbladder attack." An attack happens when a stone blocks the cystic duct or the opening to the gallbladder. This blockage increases the pressure inside the organ as it tries to contract.

Gallstones
Gallstones

The result is a sudden, intense, cramp-like pain in the upper right abdomen. This pain usually peaks about one hour after it starts and typically subsides within five hours. Some patients also experience nausea or vomiting. In some cases, the pain is felt in the right shoulder, a phenomenon known as "Collin's sign."

If the stones are not managed, they can lead to serious medical complications. Acute cholecystitis is the inflammation of the gallbladder, often caused by stones. This pain is different from a standard attack because it lasts longer than six hours.

Ultrasonography of sludge and gallstones, annotated
Ultrasonography of sludge and gallstones, annotated

Other serious issues include pancreatitis, which is inflammation of the pancreas. This occurs if a stone slips into the pancreatic duct or the ampulla of Vater. There is also a risk of ascending cholangitis, a dangerous infection of the bile ducts. In rare cases, a very large stone can erode through the gallbladder wall and enter the small intestine, causing an obstruction known as gallstone ileus.

Many factors can increase the risk of developing gallstones. Women and people over the age of 40 are at a higher risk. Obesity, diabetes, and rapid weight loss are also known risk factors.

Prevalence2
Prevalence2

Diet plays a significant role as well. A low intake of nutrients like magnesium, calcium, and vitamin C may increase risk. Interestingly, certain foods like wine and whole-grain bread might actually decrease the risk. Ethnicity also plays a part in how common these stones are. For instance, 48% of Native Americans experience gallstones, while the rate in parts of Africa is as low as 3%.

In developed countries, between 10% and 15% of adults experience gallstones. In 2013, gallbladder and biliary-related diseases affected approximately 104 million people. This accounted for about 1.6% of the global population.

Risks
Risks

If a person experiences frequent gallbladder attacks, doctors usually recommend surgery to remove the gallbladder. This is often performed under general anesthesia using either small incisions or one larger incision.

Benefits
Benefits

In rare instances where surgery is not an option, doctors may use medication to dissolve the stones or use lithotripsy to break them down. Once the gallbladder is removed, the medical outcomes for patients are generally positive.

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🖼️ Images & Media (17)
File:Human gallstones 2015 G1.jpg
Human gallstones 2015 G1.jpg
File:Types of Gallstones.jpg
Types of Gallstones.jpg
File:Gallstone µCT.jpg
Gallstone µCT.jpg
Gallenstein FRONT.OGG
File:Ultrasonography of sludge and gallstones, annotated.jpg
Ultrasonography of sludge and gallstones,...
File:Big Gallstone.JPG
Big Gallstone.JPG
File:Gallstones.png
Gallstones.png
File:StonesXray.PNG
StonesXray.PNG
File:Gallstones.JPG
Gallstones.JPG
File:Benefits.png
Benefits.png
File:LargeGstoneMark.png
LargeGstoneMark.png
File:Risks.png
Risks.png

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