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Flagellum

life science Maturity 11-13 Next article →

A flagellum is a hair-like appendage used by many organisms to achieve motility, or movement. The name comes from the Latin word for "whip," which describes its lashing motion. Flagella are found on various life forms, including animal sperm cells, fungal spores known as zoospores, and many microorganisms.

Chlamydomonas TEM 09
Chlamydomonas TEM 09

These structures are vital for survival in many environments. For example, the bacterium Helicobacter pylori uses its flagella to swim through the stomach. This allows it to reach the mucous lining of the epithelium. Once there, it can colonize the area and potentially cause gastritis or ulcers.

Flagellum-beating
Flagellum-beating

Across the three domains of life—Bacteria, Archaea, and Eukaryota—flagella perform the same function. However, they differ greatly in structure and how they move. Prokaryotic flagella, found in bacteria and archaea, use a rotary movement like a propeller. Eukaryotic flagella use a bending movement, lashing back and forth.

In eukaryotes, flagella contain microtubules and a protein called dynein to create this bending. Archaea have a structure called an archaellum to distinguish it from bacterial versions. While eukaryotic flagella and cilia are structurally identical, they differ in length and specific function.

Eukarya Flagella
Eukarya Flagella

The bacterial flagellum is a highly complex machine requiring over 50 different proteins. It consists of a helical filament made of protein subunits called flagellin. This filament is a hollow tube about 20 nanometers thick. A part called the hook allows the filament to point away from the cell. The structure also includes a shaft and a basal body. In gram-negative bacteria, the basal body uses four specific rings: the L, P, M, and S rings.

Eukaryotic flagellum
Eukaryotic flagellum

These rings act like bearings to support the rotating shaft.

Movement in bacteria is driven by a rotary engine called the Mot complex. This engine is located at the anchor point on the inner cell membrane. It is powered by proton-motive force, which is the flow of protons across the membrane. This flow creates a concentration gradient that turns the rotor. The rotor can operate at speeds between 6,000 and 100,000 rpm. However, when the filament is attached, the speed usually drops to 200 to 1,000 rpm.

Chlamydomonas TEM 17
Chlamydomonas TEM 17

A protein named FliG acts as a molecular switch to change rotation direction.

Bacteria use these rotations to navigate their environment through a process called a biased random walk. They perform "runs" and "tumbles" to move toward attractants or away from repellents. Counterclockwise rotation acts as a "thruster mode," where the flagella lag behind the body. Clockwise rotation is called "traction mode," where the body follows the flagella. Some bacteria, like Vibrio species, use a sodium ion pump instead of a proton pump. This allows them to achieve remarkable speeds relative to their size. Some bacteria can move at 60 cell lengths per second.

Eukarya Flagella
Eukarya Flagella

Scientists have long debated how the flagellum evolved. One major theory is that it evolved from the type-three secretion system (TTSS). The TTSS is a structure used by many gram-negative bacteria to inject proteins. Both systems share many similar proteins and a similar number of components. Some researchers suggest they evolved from a common ancestor. Others believe they may have evolved in parallel. Despite arguments that the flagellum is "irreducibly complex," many mutations show the system is actually very flexible. It can lose or gain proteins and still function effectively.

Flagellar arrangements also vary significantly between different species. Scientists use the Greek root "tricho," meaning hair, to name these patterns. Monotrichous bacteria, such as Vibrio cholerae, possess only a single polar flagellum. Amphitrichous bacteria have one flagellum at each of two opposite ends. Lophotrichous bacteria have a tuft or crest of multiple flagella. These different arrangements allow different organisms to master their specific watery environments.

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🖼️ Images & Media (6)
File:Difference Between Prokaryote and Eukaryote Flagella.svg
Difference Between Prokaryote and...
File:Eukarya Flagella.svg
Eukarya Flagella.svg
File:Eukaryotic flagellum.svg
Eukaryotic flagellum.svg
File:Chlamydomonas TEM 09.jpg
Chlamydomonas TEM 09.jpg
File:Chlamydomonas TEM 17.jpg
Chlamydomonas TEM 17.jpg
File:Flagellum-beating.svg
Flagellum-beating.svg
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