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Thyroid

life science Maturity 9-11 Next article →

The thyroid is a vital endocrine gland found in vertebrates. In humans, it is a butterfly-shaped organ located in the neck. It sits just below the Adam's apple, surrounding the cricoid and tracheal cartilages.

Illu08 thyroid
Illu08 thyroid

The gland consists of two connected lobes, a left and a right. A thin band of tissue called the isthmus connects these two lobes. In adults, the entire gland typically weighs about 25 grams. Each individual lobe is roughly 5 cm long, 3 cm wide, and 2 cm thick. The isthmus is smaller, measuring about 1.25 cm in both height and width.

At a microscopic level, the thyroid is composed of specific functional units. The primary unit is the thyroid follicle, which is a tiny spherical grouping of cells. These follicles are between 0.02 and 0.9 mm in diameter.

Thyroid-histology
Thyroid-histology

Each follicle is lined with a single layer of follicular cells, also known as thyrocytes. Inside the follicle is a fluid-filled space called the lumen. This lumen contains a substance called colloid. The colloid is a concentrated solution of thyroglobulin, which is a protein used to make hormones. Scattered among these follicles are parafollicular cells, or C cells, which serve a different purpose.

The thyroid produces three essential hormones to regulate body functions. The first two are thyroid hormones: triiodothyronine (T3) and thyroxine (T4). These are created by combining iodine with the amino acid tyrosine. T3 contains three iodine atoms, while T4 contains four.

Thyroid hormone synthesis
Thyroid hormone synthesis

These hormones are critical for the basal metabolic rate. They influence how the body breaks down fats and uses glucose. They also affect heart rate, breathing, and how much oxygen the body consumes. The third hormone is calcitonin, a peptide hormone secreted by the parafollicular cells. Calcitonin plays a specific role in maintaining calcium homeostasis, or the balance of calcium in the body.

Control of these hormones works through a complex chemical communication system. The process begins in the brain with the hypothalamus. The hypothalamus produces thyrotropin-releasing hormone (TRH). This hormone signals the anterior pituitary gland to release thyroid-stimulating hormone (TSH).

Thyroid system
Thyroid system

When TSH reaches the thyroid, it stimulates the follicular cells to produce T3 and T4. This system uses a negative feedback loop to maintain balance. If hormone levels become too high, the brain reduces the release of TRH and TSH. This ensures the body maintains the precise levels of hormones needed for health.

The development of the thyroid begins very early in an embryo. At about three to four weeks of gestation, the thyroid appears as a growth in the floor of the pharynx. It then descends toward the neck through a narrow canal called the thyroglossal duct.

Gray42
Gray42

By the end of the fifth week, this duct usually disappears. The thyroid eventually reaches its final position in front of the trachea. By 11 weeks, TSH becomes measurable in the fetus. By 18 to 20 weeks, the production of thyroxine (T4) reaches levels that allow the fetus to be self-sufficient. This is vital because the fetus needs these hormones for healthy brain development.

While the thyroid follows a general pattern, there are many anatomical variations. Some people possess a third lobe called a pyramidal lobe, also known as Lalouette's pyramid.

Sobo 1906 444
Sobo 1906 444

This lobe is a remnant of the thyroglossal duct and is present in 18.3% to 44.6% of people. Another variation is Zuckerkandl's tubercle, which is a small horn at the back of the lobes. The gland is also attached to the neck structures by Berry's ligament. This ligament causes the thyroid to move up and down when a person swallows. These variations show how much individual anatomy can differ.

When the thyroid does not function correctly, it leads to various medical conditions. Hyperthyroidism occurs when the gland secretes excessive amounts of thyroid hormones. A common cause of this is Graves' disease, which is an autoimmune disorder. Conversely, hypothyroidism occurs when there is a deficiency in hormone secretion.

The thyroid gland in health and disease (1917) (14780977681)
The thyroid gland in health and disease (1917) (14780977681)

In many regions, the most common cause of hypothyroidism is a lack of iodine. In iodine-sufficient areas, Hashimoto's thyroiditis is a frequent cause. In areas lacking iodine, hypothyroidism is a leading cause of preventable intellectual disability in children.

Understanding these connections helps scientists treat metabolic and developmental disorders.

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🖼️ Images & Media (9)
File:Illu08 thyroid.jpg
Illu08 thyroid.jpg
File:Sobo 1906 444.png
Sobo 1906 444.png
File:Thyroid-histology.jpg
Thyroid-histology.jpg
File:Gray42.png
Gray42.png
File:Thyroid system.svg
Thyroid system.svg
File:Thyroid hormone synthesis.png
Thyroid hormone synthesis.png
File:The thyroid gland in health and disease (1917) (14780980651).jpg
The thyroid gland in health and disease...
File:Thespiae 431-424 BC.jpg
Thespiae 431-424 BC.jpg
File:The thyroid gland in health and disease (1917) (14780977681).jpg
The thyroid gland in health and disease...
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