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Testicular cancer

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Testicular cancer is a disease that develops in the testicles. These organs are a vital part of the male reproductive system. While the disease can be serious, it is considered highly treatable. Most patients can achieve a cure if the cancer is found early.

Testicular cancer
Testicular cancer

This condition often affects younger men. Most cases occur in males between the ages of 20 and 34. It is very rare for the disease to appear before age 15.

Doctors look for specific physical changes to identify the disease. A common first sign is a painless lump or swelling in a testicle. A person might also feel a dull ache in the lower abdomen or scrotum. Some describe a feeling of "heaviness" in the scrotum. In some cases, hormonal effects can cause breast enlargement, known as gynecomastia. If the cancer spreads to lymph nodes in the back, it may cause low back pain. If it reaches the lungs, a person might cough or feel short of breath.

Relative incidences of testicular tumors
Relative incidences of testicular tumors

To find the cancer, doctors follow a specific diagnostic process. First, they perform a physical exam and may use an ultrasound. An ultrasound uses sound waves to see if a lump is solid or cystic. Next, doctors use blood tests to look for tumor markers. These are specific proteins like alpha-fetoprotein or human chorionic gonadotropin. To be certain, a surgeon performs an inguinal orchiectomy. This is the surgical removal of the testicle through an incision in the groin. Doctors do not use a simple biopsy because it might cause cancer cells to spread into the scrotum.

Seminoma
Seminoma

Once the tissue is removed, a pathologist examines it under a microscope. This helps determine the exact type of cancer through histology. Most testicular cancers, over 95%, are germ cell tumors. These are divided into two main groups: seminomas and non-seminomas.

S16-1063 Ranochak, T MGCT- Embryonal + Seminoma + Yolk Sac
S16-1063 Ranochak, T MGCT- Embryonal + Seminoma + Yolk Sac

Non-seminomas include types like embryonal carcinoma and yolk sac tumors. Other types of tumors include sex-cord stromal tumors and lymphomas. These stromal tumors come from cells like Leydig cells or Sertoli cells.

Relative incidences of testicular tumors
Relative incidences of testicular tumors

Scientists have studied the biological mechanisms behind these tumors. Most germ cell tumors contain too many chromosomes. They are often triploid or tetraploid, meaning they have extra sets of genetic material. About 80% of these cancers contain an isochromosome 12p. This is a specific type of extra genetic material on chromosome 12. Certain risk factors are linked to how these cells develop. These include cryptorchidism, which is when a testicle does not descend properly. Other risks include family history and certain medical conditions like Klinefelter syndrome.

There are important statistics regarding the impact of this disease. In 2015, about 686,000 people were affected by testicular cancer globally. That year, there were 9,400 deaths reported. This was an increase from 7,000 deaths recorded in 1990. In the United States, the five-year survival rate is approximately 95%. Even when the cancer has spread widely, chemotherapy can offer a cure rate greater than 80%. However, outcomes are much better when the disease remains localized to the testis.

Treatment options depend on the stage and type of the cancer. Doctors may use surgery to remove the affected area. They may also use radiation therapy or chemotherapy. In some cases, stem cell transplantation is required. Treatment can be difficult and may lead to infertility. Patients and their caregivers often face significant psychological stress. This stress can come from fears of the cancer returning or changes in social life. Understanding the disease helps doctors provide better care for every patient.

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Testicular cancer.jpg
File:Seminoma.jpg
Seminoma.jpg
File:S16-1063 Ranochak, T MGCT- Embryonal + Seminoma + Yolk Sac.jpg
S16-1063 Ranochak, T MGCT- Embryonal +...
File:Relative incidences of testicular tumors.png
Relative incidences of testicular tumors.png
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