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Strigolactone

life science Maturity 5-7 Next article →

Strigolactones are a diverse group of chemical compounds produced by plant roots. Because these molecules act as signaling agents that regulate growth, scientists classify them as phytohormones, or plant hormones. These chemicals are vital for how a plant interacts with its environment and manages its own physical structure. They function as messengers that communicate with both beneficial organisms in the soil and the plant's own internal systems.

Strigolactones general chemical structure
Strigolactones general chemical structure

Chemically, all strigolactones share a common core structure. This structure consists of a tricyclic lactone, labeled as the A-B-C part, which is linked to a hydroxymethyl butenolide, known as the D part. While the A-B-C section varies between different species, the D ring remains quite constant. Researchers believe the biological activity of these molecules relies heavily on this D ring. In fact, studies show that if the C-D section of the molecule is modified, the molecule loses its ability to function.

(+)-Strigol chemical structure
(+)-Strigol chemical structure

Strigolactones drive three distinct physiological processes in nature. First, they trigger the germination of parasitic organisms, such as plants in the genus Striga. These parasites grow on the host plant's roots to survive. Second, they facilitate mutualistic associations with symbiotic fungi, specifically arbuscular mycorrhizal fungi. These fungi recognize the plant and provide essential nutrients like phosphate. Third, strigolactones act as branching inhibition hormones. They prevent excessive bud growth at stem terminals, which regulates the plant's overall shape.

Striga asiatica
Striga asiatica

The discovery of these molecules began in 1966 when they were first isolated from the roots of cotton plants. Before this, scientists knew that root extracts were necessary to start the germination of parasitic Striga lutea. The isolation of strigolactones finally identified the specific molecule responsible for this stimulation. Later, researchers identified similar compounds like sorgolactone and alectrol. Because these molecules also contained the characteristic lactone group, they were classified as strigolactones. Interestingly, strigolactones can induce parasitic plant germination in trace amounts, as little as 5 parts per million.

Sorgolactone chemical structure
Sorgolactone chemical structure

Plants create strigolactones through a complex biosynthetic pathway starting from carotenoids. The first step involves the isomerization of the 9th chemical bond of beta-carotene. This step is performed by the enzyme DWARF27, or D27, which requires iron as a cofactor. Next, the enzyme CCD7 catalyzes the separation of 9-cis-beta-carotene into 9-cis-aldehyde and beta-ionone. Then, the enzyme CCD8 rearranges the aldehyde to produce carlactone. Carlactone serves as the essential precursor for all strigolactones. Finally, proteins like MAX1 are thought to catalyze the oxidative steps that turn carlactone into more complex strigolactones.

5-Deoxystrigol chemical structure
5-Deoxystrigol chemical structure

There is also a deep connection between strigolactone synthesis and the production of abscisic acid (ABA). Both pathways share a common group of enzymes, specifically the 9-cis-epoxycarotenoid dioxygenase (NCED) family. Research on mutant plants showed that when NCED enzymes were defective, plants had low levels of both ABA and strigolactones in their roots. This suggests a shared enzymatic machinery between the two hormones. While the exact connection remains unclear, the correlation is a significant part of plant chemistry.

Lotus japonicus
Lotus japonicus

Strigolactones also manage plant architecture by interacting with another hormone called auxin. While auxin regulates secondary growth, strigolactones control how auxin is moved through the plant. When present in stem terminals, strigolactones block the expression of PIN1, which are transport proteins. In mutant plants lacking strigolactones, PIN1 is over-expressed, leading to excessive auxin transport and abnormal branching. This demonstrates how strigolactones act as a master regulator for the plant's physical development.

Orobanchol chemical structure
Orobanchol chemical structure
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🖼️ Images & Media (9)
File:Strigolactones general chemical structure.png
Strigolactones general chemical structure.png
File:Striga asiatica.jpg
Striga asiatica.jpg
File:(+)-Strigol_chemical_structure.png
(+)-Strigol_chemical_structure.png
File:Strigyl_acetate_chemical_structure.png
Strigyl_acetate_chemical_structure.png
File:Orobanchol_chemical_structure.png
Orobanchol_chemical_structure.png
File:Orobanchyl_acetate_chemical_structure.png
Orobanchyl_acetate_chemical_structure.png
File:5-Deoxystrigol_chemical_structure.png
5-Deoxystrigol_chemical_structure.png
File:Sorgolactone_chemical_structure.png
Sorgolactone_chemical_structure.png
File:Lotus japonicus.jpg
Lotus japonicus.jpg
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