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Steroid

life science Maturity 7-9 Next article →

Steroids are very important organic compounds found in many living things. They play two main roles in the bodies of animals, plants, and fungi. First, they are parts of cell membranes. A membrane is the thin layer around a cell. Steroids help these membranes stay fluid, which means they stay flexible. Second, steroids work as signaling molecules. They help cells send messages to one another. Some well-known steroids include cholesterol and sex hormones like testosterone and estradiol.

Cholesterol lettering numbering
Cholesterol lettering numbering

Every steroid has a specific shape called a nucleus. This core structure is known as gonane. It is made of seventeen carbon atoms bonded together. These atoms form four rings that are fused together. Three of these are six-member rings called cyclohexane rings. The fourth is a five-member ring called a cyclopentane ring.

Trimethyl steroid-nomenclature
Trimethyl steroid-nomenclature

Steroids can change based on what is attached to this core. They can have different groups or different numbers of carbon atoms. Some steroids even have a ring cut out of them. When one ring is cut, it becomes a secosteroid. One example of this is vitamin D3.

Cholestane
Cholestane

Scientists have studied these molecules for a long time. The name "steroid" comes from the word cholesterol. This word was first described from gall stones. It uses the Ancient Greek words "chole," meaning bile, and "stereos," meaning solid.

5alpha5betaSteroidIUPAC
5alpha5betaSteroidIUPAC

Most steroids are named after a parent structure. This parent structure acts like a skeleton for the molecule. For example, many steroids are built on a cholestane framework. Scientists use special rules to name them. They use letters like alpha and beta to show how parts are arranged in space.

Cholesterol lettering numbering
Cholesterol lettering numbering

Cells use a specific way to build these molecules. All steroids start from a molecule called squalene. This molecule goes through a process called cyclization to form a sterol. Different living things use different sterols as their starting point. Animals use cholesterol to build their steroids. Fungi use a molecule called lanosterol. Plants use a molecule called cycloartenol.

Sterol synthesis
Sterol synthesis
Steroidogenesis
Steroidogenesis

This shows how different life forms use similar building blocks.

You can think of a steroid like a building made of blocks. The four rings are the main frame of the house. The different groups attached to the rings are like windows or doors. By adding or moving these parts, the cell creates different tools. Some tools help the cell stay strong. Other tools help the cell talk to its neighbors. This is why hundreds of different steroids exist in nature. They allow life to be very complex and organized.

Sterol synthesis
Sterol synthesis
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🖼️ Images & Media (9)
File:Trimethyl steroid-nomenclature.svg
Trimethyl steroid-nomenclature.svg
File:5alpha5betaSteroidIUPAC.png
5alpha5betaSteroidIUPAC.png
File:Cholesterol lettering numbering.svg
Cholesterol lettering numbering.svg
File:Cholestane.svg
Cholestane.svg
File:Cholecalciferol.svg
Cholecalciferol.svg
File:Cyclopamine.svg
Cyclopamine.svg
File:Sterol synthesis.svg
Sterol synthesis.svg
File:Mevalonate pathway.svg
Mevalonate pathway.svg
File:Steroidogenesis.svg
Steroidogenesis.svg
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