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Neuron

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A neuron is a specialized, excitable cell that functions within a neural network. These cells are the primary components of nervous tissue in almost all animals. They work by firing electrical signals known as action potentials. These signals allow the nervous system to receive, conduct, and process impulses. The nervous system is divided into the central nervous system, which includes the brain and spinal cord, and the peripheral nervous system.

Structural classification of neurons by polarity hariadhi
Structural classification of neurons by polarity hariadhi

While neurons are essential for animal life, plants and fungi do not possess them.

The signaling process is a complex mix of electrical and chemical events. Every neuron is enclosed by a plasma membrane, which is a bilayer of lipid molecules. This membrane acts as an electrical insulator. However, it contains embedded protein structures like ion channels and ion pumps. These proteins manage the movement of ions such as sodium, potassium, chloride, and calcium. The interaction between these channels and pumps creates a voltage difference across the membrane.

All-or-none law en
All-or-none law en

When the voltage changes enough over a short time, the neuron generates an all-or-nothing electrochemical pulse called an action potential. This pulse travels rapidly down the axon to activate synaptic connections.

Neurons communicate with one another through specialized connections called synapses. Most signals cross from the axon of one neuron to the dendrite of another. However, synapses can also connect an axon to an axon or a dendrite to a dendrite. At the end of the axon, specialized structures called synaptic boutons release minute amounts of chemical neurotransmitters.

Neurotransmitters
Neurotransmitters

These chemicals cross the synaptic gap to reach the target cell. This chemical transmission allows the signal to pass from a presynaptic neuron to the next cell. The resulting signals can be excitatory, which increases voltage, or inhibitory, which reduces it.

The anatomy of a neuron is highly specialized for this transmission. The soma, or cell body, is a compact structure containing the nucleus. Most protein synthesis occurs here, supported by microscopic clumps called Nissl bodies.

SUM 110913 Cort Neurons 2.5d in vitro 488 Phalloidin no perm 4 cmle-2
SUM 110913 Cort Neurons 2.5d in vitro 488 Phalloidin no perm 4 cmle-2

Extending from the soma are dendrites, which are branched filaments. These branches often form fractal patterns known as a dendritic tree.

PurkinjeCell
PurkinjeCell

The axon is a long, cable-like projection that carries signals away from the soma. It begins at a swelling called the axon hillock, which serves as the spike initiation zone. The axon ends at axon terminals, where it can transmit signals to other cells.

Chemical synapse schema cropped
Chemical synapse schema cropped

Neurons are generally classified into three functional types. Sensory neurons respond to external stimuli like light, sound, or touch. They send these signals to the spinal cord and then to the sensorial areas of the brain. Motor neurons carry signals from the brain and spinal cord to control muscle contractions or glandular output. Finally, interneurons act as connectors between other neurons within the brain or spinal cord. When these different neurons connect functionally, they form a neural circuit.

Evolutionary history shows that the ability to generate electrical signals is an ancient innovation. Molecular evidence suggests this capability first appeared roughly 700 to 800 million years ago during the Tonian period. The predecessors of modern neurons were likely peptidergic secretory cells. Over time, these cells gained new gene modules. These modules allowed them to create ion channels and post-synaptic scaffolds. This transition enabled the development of fast electrical signaling in early animals.

The scale of neurons can be truly immense. While a soma might only be 10 to 25 micrometers in diameter, an axon can be much longer. In humans, a single motor neuron axon can exceed 1 meter in length to reach from the spine to the toes. Sensory neurons in adults can have axons running over 1.5 meters long. Even giraffes possess single axons that run several meters along their necks. Scientists have studied these massive structures using the squid giant axon, which can be 0.5 to 1 millimeter thick.

GFPneuron
GFPneuron
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🖼️ Images & Media (12)
File:Gyrus Dentatus 40x.jpg
Gyrus Dentatus 40x.jpg
File:SUM 110913 Cort Neurons 2.5d in vitro 488 Phalloidin no perm 4 cmle-2.png
SUM 110913 Cort Neurons 2.5d in vitro 488...
File:GFPneuron.png
GFPneuron.png
File:Structural_classification_of_neurons_by_polarity_hariadhi.svg
Structural_classification_of_neurons_by_po...
File:Neurotransmitters.jpg
Neurotransmitters.jpg
File:Chemical synapse schema cropped.jpg
Chemical synapse schema cropped.jpg
File:Neuro Muscular Junction.png
Neuro Muscular Junction.png
File:All-or-none law en.svg
All-or-none law en.svg
File:Golgi Hippocampus.jpg
Golgi Hippocampus.jpg
File:Purkinje cell by Cajal.png
Purkinje cell by Cajal.png
File:PurkinjeCell.jpg
PurkinjeCell.jpg
File:Guillain-barré syndrome - Nerve Damage.gif
Guillain-barré syndrome - Nerve Damage.gif
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