Some mushrooms can make you sick. 
Some mushrooms can make you sick. 

Some mushrooms can make people very sick. This happens if someone eats a mushroom with toxins. Toxins are bad substances made by the fungus. 
Most people get sick by mistake. They think a toxic mushroom is a safe one to eat. This happens because they look very similar. For example, some poisonous mushrooms look like white puffballs.
To stay safe, you should cut a puffball in half. This helps you see if a bad mushroom is inside. Other mushrooms can be tricky too. Jack-O-Lantern mushrooms look like tasty chanterelles. 
Symptoms can be mild or very bad. Some toxins only hurt your stomach. They cause vomiting or diarrhea. Other toxins are much more dangerous. They can attack your liver or kidneys. 
Some toxins do not go away with heat. Cooking the mushroom will not make it safe to eat. This is why you must know your mushrooms well. Always study them before you pick them.
Mushroom poisoning happens when someone eats a fungus containing toxic substances. These toxins are secondary metabolites produced by the fungus itself. Most poisonings occur because people mistake a toxic mushroom for an edible one. This mistake often happens due to a close resemblance in color or shape. Many mushrooms look very similar to others that are safe to eat. To stay safe, foragers must learn to recognize both types. They should study the mushrooms they want to collect very carefully. 
How a person feels depends on the specific toxin they ate. Some toxins only cause gastrointestinal upset, like vomiting or diarrhea. Other toxins are much more dangerous and can lead to organ failure. For example, the toxin amatoxin can cause severe liver damage. This toxin is found in the death cap mushroom. It often shows no symptoms for 6 to 12 hours. After that, a person may feel very sick for a day. Severe damage to the liver or kidneys can follow this stage.
Different mushrooms contain very different kinds of poisons. The genus Cortinarius contains orellanine, which can cause kidney failure. This toxin might not show symptoms for 3 to 20 days. The genus Gyromitra contains gyromitrin, which can cause brain damage or seizures. Stomach acids in the body turn gyromitrin into monomethylhydrazine. Another mushroom, the Jack-o-Lantern, contains illudins that cause stomach upset. These mushrooms belong to the genus Omphalotus. 
Scientists and experts work hard to classify these many species. There are about 100,000 known fungi species in the world today. Of those, about 100 are known to be poisonous to humans. New species are discovered at a rate of 800 every year. This makes it hard to keep old identification guides accurate. Some mushrooms are even reclassified from edible to poisonous over time. For instance, the Amanita phalloides is a major cause of fatal poisonings. It can be mistaken for the Asian paddy-straw mushroom. 
Learning about mushrooms helps us understand the natural world. You can see how similar a deadly mushroom can look to a tasty one. For example, an immature Amanita can look like a white puffball. Foragers are told to cut puffballs in half to check inside. This reveals if a developing Amanita is hidden within. Some mushrooms, like the edible shaggy mane, are safe to eat. Others, like the chanterelle, are also safe and delicious. 
Mushroom poisoning occurs when a person eats a fungus containing toxic substances. These toxins are known as secondary metabolites, which are chemicals produced by the fungus itself. Most cases of poisoning happen because a person misidentifies a toxic mushroom as an edible species. This mistake is usually caused by a close resemblance in color or general morphology, which is the physical shape and structure of the mushroom. To prevent these accidents, mushroom gatherers must study the species they intend to collect. They must also learn to recognize any similar-looking toxic species. 
The way a person feels depends on the specific toxin involved. Some toxins are merely gastrointestinal irritants. These cause vomiting and diarrhea but usually do not cause long-term damage. Other toxins are much more dangerous and can lead to organ failure or death. The time between eating the mushroom and feeling sick varies widely. Some toxins show effects within minutes, while others may not cause symptoms for weeks. This delay can make it difficult to realize that a mushroom was the cause of the illness.
One of the most dangerous toxins is amatoxin, which is found in the genus Amanita. The principal toxin in the death cap mushroom is called alpha-amanitin. After ingestion, there is often a period of 6 to 12 hours with no symptoms. This is followed by gastrointestinal upset, such as vomiting and profuse watery diarrhea. This stage is often caused by phallotoxins and typically lasts about 24 hours. After this, severe liver damage begins, which can continue for 2 to 3 days. In some cases, kidney damage occurs, and patients may require a liver transplant. The mortality rate for amatoxin poisoning is between 10 and 15 percent.
Other toxins target different systems in the body. Orellanine is a deadly toxin found in the genus Cortinarius. It acts as a redox cycler, which is a type of chemical reaction, similar to the substance paraquat. Orellanine can cause kidney failure, but symptoms may not appear for 3 to 20 days. Around day 11, the process of kidney failure typically begins. Symptoms can include thirst, vomiting, headache, and fatigue. Another dangerous toxin is gyromitrin, found in the genus Gyromitra. When consumed, stomach acids convert gyromitrin into monomethylhydrazine (MMH). This metabolic poison can cause brain damage, seizures, and the breakdown of red blood cells.
Some mushrooms cause effects that depend on what else a person has consumed. Coprine is the principal toxin in the genus Coprinus. It is generally non-lethal, but it causes illness if consumed with alcohol. This happens because coprine is metabolized into a chemical that inhibits aldehyde dehydrogenase (ALDH). If a person has alcohol in their bloodstream, the body cannot completely metabolize it. This leads to flushed skin, dizziness, and palpitations. Additionally, certain mushrooms like Amanita muscaria contain ibotenic acid and muscimol. Ibotenic acid can decarboxylate, or change chemically, into muscimol upon ingestion. This can lead to hallucinations, confusion, or sleepiness.
Identifying mushrooms correctly is a complex task because new species are discovered frequently. Scientists estimate that about 800 new species are registered every year. Out of approximately 100,000 known fungi species worldwide, about 100 are poisonous to humans. However, many older classifications are no longer sufficient because some species have been reclassified from edible to poisonous. For example, the Amanita phalloides is a major cause of fatal poisonings. It is often mistaken for the Asian paddy-straw mushroom, Volvariella volvacea, because both are light-colored. 
Foragers use specific techniques to avoid dangerous mistakes. One common danger involves immature Amanita mushrooms, often called "eggs," because they are encased in a universal veil. These can be mistaken for edible puffballs. To stay safe, foragers are encouraged to cut suspected puffballs in half. This will reveal the outline of a developing Amanita if one is hidden inside. 



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