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Molecule

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A molecule is a group of two or more atoms held together by attractive forces. These forces are known as chemical bonds. Molecules are fundamental to our understanding of the physical world. They serve as the building blocks for organic substances and most of the living world. Depending on the scientific context, the term may also include polyatomic ions. In fields like quantum physics or biochemistry, scientists often use the word molecule to describe these charged groups.

Covalent bond hydrogen
Covalent bond hydrogen

The way atoms connect determines the type of molecule formed. One type is homonuclear, meaning it consists of atoms of only one chemical element. For example, an oxygen molecule (O2) is made of two oxygen atoms. Another type is heteronuclear, which is a compound made of more than one element. Water (H2O) is a heteronuclear molecule because it contains two hydrogen atoms and one oxygen atom.

Gaudins-volume-diagrams
Gaudins-volume-diagrams

Most molecules are held together through a process called covalent bonding. In covalent bonding, atoms share pairs of electrons. These electron pairs are often called bonding pairs. This sharing creates a stable balance between attractive and repulsive forces. Some substances involve ionic bonding instead. This occurs when one atom transfers an electron to another. This creates an electrostatic attraction between oppositely charged ions, known as cations and anions.

NaF
NaF

While bonding is common, not all bonded substances are molecules. Many familiar solids, such as salts, metals, and rocks, are not made of discrete molecules. Instead, they form large crystalline networks or unit-cellular structures. For instance, diamond and quartz are covalent crystals that extend in three-dimensional patterns. Metals use metallic bonding to create condensed phases. Even glasses, which are disordered solids, consist of atoms held by bonds without forming identifiable molecules.

Pentacene on Ni(111) STM
Pentacene on Ni(111) STM

Our understanding of molecules has evolved over centuries. Ancient Greek philosophers like Leucippus and Democritus argued that the universe was made of atoms and voids. Empedocles suggested that matter was composed of four elements: fire, earth, air, and water.

Fire symbol (alchemical)
Fire symbol (alchemical)
Earth symbol (alchemical)
Earth symbol (alchemical)
Air symbol (alchemical)
Air symbol (alchemical)
Water symbol (alchemical)
Water symbol (alchemical)

In 1661, Robert Boyle hypothesized that matter consists of clusters of particles called corpuscles. In 1811, Amedeo Avogadro introduced the term "molecule" to describe these combinations.

Gaudins-volume-diagrams
Gaudins-volume-diagrams

Modern molecular science was transformed by 20th-century physics. In 1926, Jean Perrin won the Nobel Prize for proving the existence of molecules. He used methods involving Brownian motion and liquid phase systems to reach this conclusion.

Atisane3
Atisane3

Later, Linus Pauling applied quantum mechanics to the study of chemical bonds. In 1931, he published "The Nature of the Chemical Bond." This work allowed scientists to calculate molecular structures, such as the angles between bonds. He even developed hybridization theory to explain how orbitals overlap, as seen in the structure of methane (CH4).

Ch4 hybridization
Ch4 hybridization

Molecules vary greatly in size and importance. Most are far too small to see with the naked eye. Many building blocks for organic synthesis are only a few angstroms wide. An angstrom is about one billionth of a meter. However, some molecules are massive. These are called macromolecules or supermolecules. A famous example is DNA, a biopolymer that carries genetic information.

PTCDA AFM
PTCDA AFM

The study of molecules is split into two main branches. Molecular chemistry examines the laws of how molecules interact to form or break bonds. Molecular physics focuses on the laws governing the structure and properties of the molecules themselves. Though the distinction is often vague, both fields are essential. They help us understand everything from the gases in our atmosphere to the proteins in our bodies. Molecules make up our food, vitamins, sugars, and fats, forming the very basis of life.

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🖼️ Images & Media (14)
File:PTCDA AFM.jpg
PTCDA AFM.jpg
File:Pentacene on Ni(111) STM.jpg
Pentacene on Ni(111) STM.jpg
File:TOAT AFM.png
TOAT AFM.png
File:Fire_symbol_(alchemical).svg
Fire_symbol_(alchemical).svg
File:Earth_symbol_(alchemical).svg
Earth_symbol_(alchemical).svg
File:Air_symbol_(alchemical).svg
Air_symbol_(alchemical).svg
File:Water_symbol_(alchemical).svg
Water_symbol_(alchemical).svg
File:Gaudins-volume-diagrams.jpg
Gaudins-volume-diagrams.jpg
File:Ch4_hybridization.svg
Ch4_hybridization.svg
File:Covalent bond hydrogen.svg
Covalent bond hydrogen.svg
File:NaF.gif
NaF.gif
File:Atisane3.png
Atisane3.png

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