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Membrane potential

life science Maturity 5-7 Next article →

Membrane potential, also known as membrane voltage, is the difference in electric potential between the interior and the exterior of a biological cell.

Cell membrane detailed diagram en
Cell membrane detailed diagram en

It represents the amount of work required to move a small positive charge across the cell membrane from the outside to the inside. This electrical difference is essential for life. It allows cells to function as tiny batteries that power various molecular devices. In specialized cells, such as neurons and muscle cells, this potential is used to transmit signals throughout the body.

The mechanism behind this voltage relies on the structure of the cell membrane. All animal cells are surrounded by a lipid bilayer, which is a thin layer of fats. Embedded within this bilayer are various proteins that act as gatekeepers. Some of these are ion pumps, which actively push ions across the membrane to create concentration gradients. Others are ion channels, which allow ions to flow across the membrane down their electrochemical gradients.

Scheme facilitated diffusion in cell membrane-en
Scheme facilitated diffusion in cell membrane-en

These proteins work together to maintain the voltage across the two sides of the membrane.

To understand how the voltage forms, we must look at ion concentration gradients. Ions are charged particles, such as potassium (K+), sodium (Na+), and chloride (Cl−). In a typical cell, potassium is at a high concentration inside, while sodium and chloride are at high concentrations outside.

Diffusion.en
Diffusion.en

If a membrane is selectively permeable to potassium, these positive ions will diffuse from the high-concentration interior to the low-concentration exterior. This movement leaves behind uncompensated negative charges inside the cell. This separation of charges creates the membrane potential, which is physically located in the immediate vicinity of the membrane.

There are different states of membrane potential depending on the cell's activity. In most cells, the potential is held at a stable value called the resting potential. For neurons, this resting potential typically ranges from −80 to −70 millivolts (mV).

Action potential ion sizes
Action potential ion sizes

When the charge changes, it is described in specific ways. If the interior voltage becomes less negative, the process is called depolarization. If the interior becomes more negative, it is called hyperpolarization. These shifts are caused by the opening or closing of specific ion channels.

In electrically excitable cells, these shifts can become very dramatic. A sufficiently large depolarization can trigger an action potential. This is a rapid and significant change in membrane potential that lasts only about 1 to 100 milliseconds.

LGIC
LGIC

During an action potential, the polarity of the membrane often reverses. These events are driven by voltage-gated ion channels, which are proteins that respond to changes in the electric field. Because these channels are controlled by the voltage they help create, they can form complex feedback loops that result in oscillations or regenerative events.

The physics of this system involves two main forces: electrical force and diffusion. Diffusion is the statistical tendency of particles to move from areas of high concentration to low concentration. Electrical force is the attraction between opposite charges and the repulsion between similar charges.

Basis of Membrane Potential2-en
Basis of Membrane Potential2-en

While ions naturally want to diffuse down their concentration gradients, the resulting voltage creates an electrical force that opposes that movement. Eventually, these two forces reach an equilibrium where the flow of ions stops.

Measuring these tiny voltages requires precision. By convention, the zero potential value is assigned to the outside of the cell. The membrane potential is then measured as the potential of the inside relative to that zero. Typical values for many cells range from −80 mV to −40 mV. This means the interior is usually negative compared to the exterior. This electrical system is the foundation for how complex organisms process information and coordinate movement through electrical signaling.

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🖼️ Images & Media (12)
File:Basis of Membrane Potential2-en.svg
Basis of Membrane Potential2-en.svg
File:Electric dipole.PNG
Electric dipole.PNG
File:Diffusion.en.svg
Diffusion.en.svg
File:Cell membrane detailed diagram en.svg
Cell membrane detailed diagram en.svg
File:Scheme facilitated diffusion in cell membrane-en.svg
Scheme facilitated diffusion in cell...
File:Scheme sodium-potassium pump-en.svg
Scheme sodium-potassium pump-en.svg
File:Action potential ion sizes.svg
Action potential ion sizes.svg
File:Potassium channel1.png
Potassium channel1.png
File:LGIC.png
LGIC.png
File:Cell membrane equivalent circuit.svg
Cell membrane equivalent circuit.svg
File:Cell membrane reduced circuit.svg
Cell membrane reduced circuit.svg
File:IPSPsummation.JPG
IPSPsummation.JPG
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