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Marguerite Davis

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Marguerite Davis was a pioneering American biochemist. A biochemist is a scientist who studies the chemical processes within and relating to living organisms. Her work was vital to our understanding of nutrition. She is best known for co-discovering vitamins A and B. This discovery changed how scientists look at the food required for life.

Davis was born on September 16, 1887, in Racine, Wisconsin. Her father, John Jefferson Davis, was a local physician and a botanist. He also taught at the University of Wisconsin. Growing up in this environment likely influenced her scientific path. When she was ten years old, she suffered severe burns. This happened while she was playing at a bonfire. These burns left her with a physical handicap for the rest of her life.

Her academic journey began at the University of Wisconsin in 1906. In 1908, she transferred to the University of California at Berkeley. She earned a bachelor of science degree in home economics in 1910. After graduating, she returned to the University of Wisconsin for graduate work. She did not complete a master's degree there. However, she began working as a research assistant for Elmer Verner McCollum in 1909.

Davis and McCollum focused their research on animal diets. They wanted to create food mixtures that could replace natural food. They were specifically looking for trace chemicals that are essential to life. To do this, they used a large colony of rats. Davis was responsible for caring for this colony and helping it expand. Because of her help, they performed ten or more times as many experiments as McCollum could alone. They originally called these essential substances "vitamines." This name came from their hypothesis that these substances were organic molecules called amines.

In 1913, the pair identified two distinct types of these substances. First, they found "fat-soluble A," which is a substance found in fats. They distinguished this from another substance studied by a Dutch chemist named Christiaan Eijkman. They called this second substance "water-soluble B." These findings were published in the Journal of Biological Chemistry in 1913. The paper was titled "The Necessity of Certain Lipins in the Diet during Growth."

These discoveries were later renamed Vitamins A and B after much research on rats. This work paved the way for much more research into human and animal nutrition. Davis was highly influential in building scientific infrastructure. She founded the nutrition laboratories at the University of Wisconsin–Madison. She also worked for the Squibb Pharmaceutical Company in New Jersey. Later, she helped Rutgers University form a nutrition lab within its Ernest Mario School of Pharmacy.

Davis's career included significant teaching and leadership roles. In 1940, she returned to the University of Wisconsin to teach and conduct research. She remained there for several years before she retired. During her time in the lab, her compensation was often low. McCollum requested a salary for her every year, but it was denied for many years. She worked without pay for five years. In her sixth and final year of work, she was paid $600.

After retiring in 1940, Davis moved back to her hometown of Racine. She lived in the family home with her brother, John Archibald "Archie" Davis. She spent her later years pursuing interests in history and gardening. She also stayed active in local civic affairs. In 1958, the Racine Women's Civic Council recognized her as a civic leader. Davis lived to be eighty years old. She died on September 19, 1967, three days after her birthday.

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