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Homology (biology)

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Homology is a fundamental concept in biology used to describe similarities between organisms. These similarities occur in anatomical structures or genetic sequences. They exist because the different organisms share a common ancestor. Even if the structures serve very different purposes today, they are related by descent. This process is known as divergent evolution. It explains how a single ancestral body plan can change over time to fit many different environments.

Homology vertebrates-en.svg<!-- This image, Homology vertebrates-en.svg, is referred to in the text! Please don't change it without also updating the text with something equally or more suitable
Homology vertebrates-en.svg<!-- This image, Homology vertebrates-en.svg, is referred to in the text! Please don't change it without also updating the text with something equally or more suitable

The mechanism of homology relies on inherited traits being passed down through generations. When a population splits into different species, they carry the same basic biological blueprint. Over long periods, natural selection may modify these structures for new uses. For example, the forelimbs of vertebrates all share a basic skeletal pattern. This pattern includes major forearm bones like the humerus, radius, and ulna. In whales, these bones form flippers for swimming. In birds, they form wings for flight. In primates, they form arms for grasping.

Homology vertebrates-en.svg<!-- This image, Homology vertebrates-en.svg, is referred to in the text! Please don't change it without also updating the text with something equally or more suitable
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Scientists categorize different types of homology to understand biological relationships. One type is serial homology, which occurs within a single animal. This happens when structures repeat along the body, such as the legs of a centipede or the vertebrae in a backbone. Another type is sequence homology, which involves DNA or proteins. Researchers look for significant similarities in these sequences to find shared ancestry. This can happen through a speciation event, creating orthologs, or a duplication event, creating paralogs.

Histone Alignment
Histone Alignment

History shows that humans have observed these patterns for centuries. Aristotle noticed biological similarities as early as 350 BC. In 1555, Pierre Belon performed systematic comparisons of bird and human skeletons.

BelonBirdSkel
BelonBirdSkel

In 1818, Étienne Geoffroy Saint-Hilaire argued that structures were shared between fishes, reptiles, birds, and mammals. The term "homology" was first used in a biological context by Richard Owen in 1843. Owen defined it as the same organ appearing in different animals under different forms. Later, in 1859, Charles Darwin used homology to support his theory of evolution. He viewed different taxa as branches on a single tree of life.

Distinguishing homology from analogy is essential for accurate biological study. Analogous structures perform similar functions but do not share a recent common ancestor. This is often called convergent evolution. For instance, the wings of an insect and the wings of a bird both allow flight. However, they evolved independently and are not homologous. Similarly, the wings of a sycamore maple seed are analogous to bird wings. They both help with gliding, but they develop from very different structures.

Homology can be found in surprising places across the animal kingdom. In mammals, the three small bones of the middle ear are homologous to the jaw bones of lizards. These bones include the malleus, incus, and stapes. In arthropods, researchers use Hox genes to study how body segments and appendages are related.

Arthropod segment Hox gene expression
Arthropod segment Hox gene expression

Even deep homologies exist at the genetic level. The pax6 genes control eye development in both vertebrates and arthropods. This was unexpected because their eyes look so different anatomically.

PAX6 Phenotypes Washington etal PLoSBiol e1000247
PAX6 Phenotypes Washington etal PLoSBiol e1000247

Understanding homology allows scientists to build the tree of life. It provides the basis for all biological classification. By comparing bones, embryos, and DNA, researchers can trace how life has changed. It connects anatomy, genetics, and developmental biology into one large picture of how living things are related.

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Homology vertebrates-en.svg<!-- This...
File:BelonBirdSkel.jpg
BelonBirdSkel.jpg
File:Acer pseudoplatanus MHNT.BOT.2004.0.461.jpg
Acer pseudoplatanus MHNT.BOT.2004.0.461.jpg
File:PAX6 Phenotypes Washington etal PLoSBiol e1000247.png
PAX6 Phenotypes Washington etal PLoSBiol...
File:Arthropod segment Hox gene expression.svg
Arthropod segment Hox gene expression.svg
File:202003 Trilobite.svg
202003 Trilobite.svg
File:202201 Common house spider.svg
202201 Common house spider.svg
File:Scolopendra subspinipes japonica (no background).png
Scolopendra subspinipes japonica (no...
File:202101 Chrysodeixis eriosoma.svg
202101 Chrysodeixis eriosoma.svg
File:202112 Japanese tiger prawn.svg
202112 Japanese tiger prawn.svg
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ABC flower developement.svg
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Eupodophis at Royal Belgian Institute of...

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