Nepedia
Back to Discover
Advanced Reader
🧬

Hepatitis

life science Maturity 11-13 death dying Next article →

This article covers sensitive topics: death_dying. Parents can manage visibility in Parental Controls.

Hepatitis is the medical term for inflammation of the liver tissue. The name comes from the Greek words "hêpar," meaning liver, and "-itis," which means inflammation.

Histopathology of acute hepatitis
Histopathology of acute hepatitis

This condition is significant because the liver performs many vital roles in the body. When the liver becomes inflamed, its ability to function can be damaged. Hepatitis can present in many ways, ranging from having no symptoms at all to causing severe liver failure. Doctors categorize the condition based on how long the inflammation lasts. Acute hepatitis is defined as inflammation that resolves within six months. Chronic hepatitis is inflammation that persists for longer than six months.

Stages of Liver disease NIDDK NIH
Stages of Liver disease NIDDK NIH

Acute viral hepatitis often follows a specific sequence of biological stages. It begins with a prodromal phase, which is the period before specific symptoms appear. During this phase, people often feel flu-like symptoms such as fatigue, nausea, vomiting, and joint pain. Some may also experience headaches or fever. In cases of hepatitis A and E, fever is more common. Later in this phase, liver-specific signs may appear, such as choluria, which is dark urine, or clay-colored stools. After one to two weeks, jaundice typically develops. Jaundice is a yellow discoloration of the skin and the whites of the eyes.

Jaundice eye
Jaundice eye

This yellowing can last for up to four weeks. During this time, the liver may become enlarged, and the person might feel pain in the upper right abdomen.

While most acute cases resolve, some can lead to a rare and life-threatening complication called fulminant hepatitis. This involves massive hepatic cell death. Fulminant hepatitis can cause coagulopathy, which is an abnormal ability for blood to clot, leading to easy bruising or bleeding. It can also cause encephalopathy, which is a state of confusion, disorientation, or sleepiness. This complication occurs most frequently in cases of hepatitis B and D co-infection. It also affects about 15% to 20% of pregnant women with hepatitis E. If the liver fails completely, it can lead to serious issues like cerebral edema or respiratory failure.

Depiction of a liver failure patient
Depiction of a liver failure patient

Chronic hepatitis is a different challenge because it often lasts for years. In its early stages, chronic hepatitis is frequently asymptomatic. This means people may not feel sick and might only discover the condition through laboratory blood tests. As the inflammation continues, it can eventually cause constitutional symptoms like fatigue and poor appetite. Chronic inflammation can also interfere with the liver's hormonal functions. This might result in acne, abnormal hair growth called hirsutism, or a lack of menstrual periods in women. If the inflammation is not controlled, it can lead to cirrhosis. Cirrhosis is the permanent scarring of the liver tissue that prevents it from working correctly.

There are many different causes for liver inflammation. Viral hepatitis is the most common cause globally. There are five main viruses: hepatitis A, B, C, D, and E.

Hepatitis B virus v2
Hepatitis B virus v2

Hepatitis A and E are usually spread through contaminated food and water. Hepatitis B, C, and D are transmitted through contact with infected blood or body fluids. Hepatitis D is a unique, defective virus that can only infect people who already have hepatitis B.

Hep D Epidemiology Figure 1
Hep D Epidemiology Figure 1

Beyond viruses, hepatitis can be caused by heavy alcohol use, certain medications, or toxins. It can also be caused by autoimmune diseases, where the immune system attacks the liver, or by metabolic issues like non-alcoholic steatohepatitis (NASH).

Infectious agents like bacteria and parasites also play a role. For example, the dog tapeworm, known as Echinococcus granulosus, can infect the liver and form cysts.

Echinococcus granulosus
Echinococcus granulosus

Bacteria such as Escherichia coli can also cause liver abscesses. The impact of hepatitis is massive on a global scale. In 2015, hepatitis A affected about 114 million people worldwide. Chronic hepatitis B affected approximately 343 million people, and chronic hepatitis C affected 142 million.

HCV structure
HCV structure

Globally, hepatitis results in more than one million deaths every year. Most of these deaths are caused indirectly by liver cancer or extensive liver scarring.

In the United States, the numbers are also significant. About 11 million people are affected by NASH, and about 5 million people have alcoholic hepatitis. While hepatitis C was once spread frequently through blood transfusions, widespread screening since 1992 has reduced that risk to 1 in 2 million. We can take action to prevent and treat these conditions. Immunizations are available to prevent hepatitis A, B, and D.

Havrix-rokote
Havrix-rokote

For chronic hepatitis C, antiviral medications are often recommended. For other types, such as NASH, doctors recommend a healthy diet and physical activity to help maintain liver health.

745 words

Where will your curiosity go next?

Keep exploring at your chosen reading level.

🖼️ Images & Media (15)
File:Jaundice eye.jpg
Jaundice eye.jpg
File:Echinococcus granulosus.JPG
Echinococcus granulosus.JPG
File:Stages of Liver disease NIDDK NIH.gif
Stages of Liver disease NIDDK NIH.gif
File:Histopathology of acute hepatitis.jpg
Histopathology of acute hepatitis.jpg
File:Hepatitis B virus v2.png
Hepatitis B virus v2.png
File:HCV structure.png
HCV structure.png
ABHD5CGI-58-the-Chanarin-Dorfman-Syndrome-...
File:Havrix-rokote.jpg
Havrix-rokote.jpg
File:WHO-UNICEF estimates of hepatitis B vaccine (HepB-BD) coverage in countries from the European WHO region in the years 2000-2015.png
WHO-UNICEF estimates of hepatitis B...
File:Hep D Epidemiology Figure 1.svg
Hep D Epidemiology Figure 1.svg
File:Depiction of a liver failure patient.png
Depiction of a liver failure patient.png
File:Hepatitis E virus.jpg
Hepatitis E virus.jpg

+ 3 more

More to explore

🔬 Go deeper

More advanced topics to explore

🪜 Step back

Simpler topics to build understanding

What is Nepedia?

A free, ad-free encyclopedia for children. Every article is written at five reading levels, so the same page works for a five-year-old and a fifteen-year-old — use the level switcher above to see this one change. No account needed to read.