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Conidium

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A conidium, or conidia in the plural, is an asexual, non-motile spore produced by a fungus.

Conidium
Conidium

The term originates from the Ancient Greek word for dust. These spores are also known as mitospores because they are generated through mitosis, a cellular process of division. Because they are produced through this process, the two new haploid cells are genetically identical to the haploid parent. This allows them to serve as a primary method for biological dispersal. They are produced exogenously, which means they develop on the outside of the fungus. In many species, such as ascomycetes and basidiomycetes, they are borne on specialized stalks called conidiophores.

Chain of conidia of an Alternaria sp. fungus PHIL 3963 lores
Chain of conidia of an Alternaria sp. fungus PHIL 3963 lores

There are two primary methods of conidiogenesis, which is the process of spore development. The first is blastic conidiogenesis. In this method, the spore is already visible before it separates from the conidiogenic hypha. The second method is thallic conidiogenesis. In this process, a cross-wall appears first, and the newly created cell then develops into a spore. Before the rise of molecular techniques at the end of the 20th century, scientists used the unique morphology of these conidiophores to identify different species. This remains a vital way to distinguish between fungi like the genus Metarhizium.

Once a conidium finds favorable conditions, it may begin germination. This process can involve the formation of germ tubes, which grow to create hyphae and fungal mycelia. Some conidia also produce conidial anastomosis tubes, or CATs. These tubes are morphologically and physiologically different from standard germ tubes. After these tubes are induced, they grow toward one another and eventually fuse. This fusion allows nuclei to pass through the fused tubes. This event is part of vegetative growth rather than sexual reproduction. Such fusion is important for some fungi when they are establishing a new colony. This specific type of tube production has been suggested to occur in 73 different fungal species.

In the genus Aspergillus, a common mold, germination follows a very specific three-stage sequence. The first stage is dormancy. During dormancy, conidia are incredibly resilient. They can remain dormant for over a year at room temperature. They can survive dehydration, changes in osmotic pressure, oxidation, and varying levels of acidity or UV exposure. This resilience is driven by central regulatory proteins. One essential protein is called wetA. In mutants where wetA is defective, the cell wall synthesis is weak, and the spore has less tolerance for harsh environments. Other proteins, such as velvet regulator proteins and heat shock proteins, also help manage growth and environmental stress.

The second stage is isotropic growth. This occurs when the conidium takes up water, causing increased intracellular osmotic pressure. This causes the spore to swell and increases its cellular diameter. During this time, the cell undergoes remodeling of the cell wall. The third stage is polarized growth. The swelling from the isotropic stage directs growth toward one side of the cell. This leads to the formation of a germ tube. This stage involves the upregulation of proteins used for DNA processing and mitosis. It also involves the synthesis of chitin, which is a major component of the fungal cell wall.

Seiridium canker 100814w
Seiridium canker 100814w

Many plant pathogens use specialized structures called conidiomata to release their spores. These structures can be about 1 mm in diameter and form masses of conidia under a host's skin. As pressure builds, they erupt through the surface to be spread by wind and rain. One type is a pycnidium, which is a flask-shaped structure. These form in the fungal tissue and release spores through a small opening called an ostiole. The other type is an acervulus, which is a simpler, cushion-like structure. Acervuli can form in various layers of a host, such as the subcuticular or intraepidermal layers. They develop a flat layer of short conidiophores that eventually split the plant's epidermis or cuticle to release the spores.

Conidia are a constant presence in our environment. An average person inhales at least 40 conidia every hour. In total, humans inhale between $10^3$ and $10^{10}$ mold conidia every day. While usually harmless, they can cause serious health issues. For example, species like Cryptostroma corticale can cause hypersensitivity pneumonitis in forest workers. In immunocompromised individuals, such as those with AIDS or organ transplants, inhaling Aspergillus can lead to aspergillosis. This is a pulmonary infection that can be very dangerous. The mortality rate for invasive fungal infections can exceed 50%, even when antifungal drugs are used. This makes the study of conidial germination and resistance a critical area of medical research.

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🖼️ Images & Media (3)
File:Conidium.png
Conidium.png
File:Chain of conidia of an Alternaria sp. fungus PHIL 3963 lores.jpg
Chain of conidia of an Alternaria sp....
File:Seiridium canker 100814w.JPG
Seiridium canker 100814w.JPG
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