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Candidiasis

life science Maturity 11-13 Next article →

Candidiasis is a fungal infection caused by yeasts in the genus *Candida*.

Candida albicans PHIL 3192 lores
Candida albicans PHIL 3192 lores

These yeasts are often part of the normal flora, which means they live naturally on our skin and inside our mouths and intestines. Usually, the human immune system and competition from other microorganisms like bacteria keep their growth in check. However, if this balance is disrupted, the yeast can multiply uncontrollably. This can lead to localized infections or, in rare cases, much more serious systemic issues. Understanding how these yeasts behave helps us manage the different types of infections they cause.

The mechanism of infection often involves an imbalance in the body's natural environment. *Candida* requires moisture to grow, which is why wearing wet swimwear for long periods can affect the skin.

Derm-57
Derm-57

In the body, the yeast can overgrow if the immune system is weakened or if the natural bacteria are removed. For example, taking antibiotic therapy can kill the bacteria that normally compete with the yeast for resources. This leaves more room and food for the *Candida* to grow. In the vagina, disturbances like hormonal changes or the use of certain detergents can also allow the yeast to take over. This overgrowth leads to inflammation and the symptoms we recognize as an infection.

Candidiasis presents in many different forms depending on where it affects the body. Mucosal candidiasis involves the mucous membranes, such as the mouth, esophagus, or genitals. Oral candidiasis is commonly known as thrush and often appears as white patches on the tongue or throat.

Esophageal candidiasis (2) PAS stain
Esophageal candidiasis (2) PAS stain

In women, vaginal candidiasis can cause intense itching and a white, cottage cheese-like discharge.

Yeast Infection
Yeast Infection

For men, an infection of the penis is known as candidal balanitis. It can cause redness, swelling, and even difficulty retracting the foreskin. There are also skin infections and nail infections, the latter of which is called onychomycosis.

Toefungus
Toefungus

Medical history shows that certain groups are more likely to experience these infections. Oral infections are most common in infants under one month old, the elderly, and people with weak immune systems. For instance, about 6% of babies under a month old have oral infections. About 20% of people with AIDS and 20% of those undergoing chemotherapy also develop the disease.

Vaginal infections are very common, with about 75% of women experiencing at least one yeast infection during their lives. Risk factors for these infections include pregnancy, diabetes, and the use of corticosteroids. People recovering from surgery or those in intensive care units are also at higher risk for more invasive types.

In rare and serious cases, the infection can become invasive or systemic. This means the yeast enters the bloodstream, a condition known as candidemia.

Vaginal swab wet mount of candida
Vaginal swab wet mount of candida

Systemic infections can spread to the central nervous system and cause symptoms similar to meningitis. For those with weakened immune systems, nearly 15% may develop a systemic illness caused by *Candida*. In the esophagus, the infection can be particularly dangerous for people with a condition called achalasia. Esophageal candidiasis can cause painful swallowing, nausea, and vomiting. It is even considered a risk factor for developing esophageal cancer in certain individuals.

Doctors use several methods to diagnose candidiasis. For mouth infections, they may simply look for white patches. For other areas, they use a swab to take a sample for microscopic examination.

Vaginal wet mount of candidal vulvovaginitis
Vaginal wet mount of candidal vulvovaginitis

One common technique involves adding a 10% potassium hydroxide (KOH) solution to a specimen. The KOH dissolves the human skin cells but leaves the *Candida* cells intact so they can be seen. Doctors can also grow the yeast on a culture medium in a lab to identify the specific species.

CHROMAgar with N glabratus, P kudriavzevii, Candida albicans and Candida tropicalis, annotated
CHROMAgar with N glabratus, P kudriavzevii, Candida albicans and Candida tropicalis, annotated

For deeper issues in the gastrointestinal tract, doctors might use an endoscopy to take a sample.

Treatment depends on the location and severity of the infection. For oral thrush, topical medications like clotrimazole or nystatin are often effective. Vaginal infections are also frequently treated with topical antifungals. If the infection is widespread or systemic, doctors may use intravenous medications. These might include fluconazole, itraconazole, or amphotericin B. For very serious cases, a class of drugs called echinocandins, such as caspofungin, may be used. By using the correct medicine for the specific type of infection, doctors can help manage the symptoms and prevent the yeast from spreading further.

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🖼️ Images & Media (10)
File:Derm-57.jpg
Derm-57.jpg
File:Yeast Infection.png
Yeast Infection.png
File:Toefungus.jpg
Toefungus.jpg
File:Vaginal swab wet mount of candida.jpg
Vaginal swab wet mount of candida.jpg
File:Candida albicans PHIL 3192 lores.jpg
Candida albicans PHIL 3192 lores.jpg
File:Vaginal wet mount of candidal vulvovaginitis.jpg
Vaginal wet mount of candidal vulvovaginitis.jpg
File:Esophageal candidiasis (2) PAS stain.jpg
Esophageal candidiasis (2) PAS stain.jpg
File:Candida Gram stain.jpg
Candida Gram stain.jpg
File:CHROMAgar with N glabratus, P kudriavzevii, Candida albicans and Candida tropicalis, annotated.jpg
CHROMAgar with N glabratus, P...
File:Mycology algorithm.png
Mycology algorithm.png
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