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Bone tumor

life science Maturity 11-13 Next article →

A bone tumor is an abnormal growth of tissue within the bone. These growths are generally classified into two main categories: benign and malignant. Benign tumors are noncancerous, while malignant tumors are cancerous. Doctors also categorize tumors based on their origin. A primary tumor begins in the bone or from bone-derived cells. A secondary tumor starts in a different part of the body and spreads to the skeleton. This spreading process is known as metastasis.

Bonetumor
Bonetumor

Secondary malignant bone tumors are quite common. They are estimated to be 50 to 100 times more common than primary bone cancers. These often originate from carcinomas in the lungs, breasts, prostates, kidneys, or thyroids. Primary tumors, however, start directly in the bone tissue. These can be benign or malignant. Common benign types include the osteochondroma, which is a type of hamartoma. Malignant primary tumors are called bone sarcomas. These include osteosarcoma, chondrosarcoma, Ewing sarcoma, and fibrosarcoma.

Giant cell tumor of bone08
Giant cell tumor of bone08

In 2020, the World Health Organization (WHO) revised how these tumors are classified. They now group them by the specific type of tissue involved. These categories include cartilage tumors and osteogenic tumors. There are also fibrogenic tumors and vascular tumors of bone. Other groups include osteoclastic giant cell-rich tumors and notochordal tumors. Doctors also look at mesenchymal tumors and hematopoietic neoplasms. This detailed classification helps medical teams choose the right treatment for each specific growth.

Symptoms of a bone tumor often result from the pressure the growth exerts on surrounding structures. A person might feel a physical lump or experience pain. This pain may increase as the tumor grows. It can often feel worse at night or while the person is at rest. If a tumor presses against a nerve, it can cause neurological signs. In some cases, a tumor may cause a pathologic fracture. This is a bone break that happens with little or no injury. Other general symptoms include fatigue, fever, weight loss, anemia, and nausea.

To find a tumor, doctors use several diagnostic tools. They often start with a plain X-ray. For more detail, they may use a CT scan or an MRI. A PET scan or bone scintigraphy can also provide important images. Doctors frequently use blood tests to check kidney and liver function. They might also check inflammatory markers or perform a serum electrophoresis. In some cases, urine is tested for Bence Jones protein. To confirm the diagnosis, a biopsy is often required. This involves taking a tissue sample through a needle or an incision for histological evaluation.

Treating bone tumors requires a multidisciplinary approach. This means a team of surgeons, radiologists, and oncologists works together. For benign tumors, doctors might simply observe them for changes. If the tumor causes pain, they may suggest surgical resection. For malignant tumors, treatment often combines surgery, chemotherapy, and radiation therapy. Some cancers, like Ewing's sarcoma, respond well to these treatments. However, others, such as chondrosarcoma, are less responsive. Surgeons may perform limb-sparing surgery to save a limb. This involves replacing the affected bone with a bone graft or artificial bone.

Newer technologies offer different ways to manage bone growths. Thermal ablation is a less invasive option for certain benign tumors. In radiofrequency ablation (RFA), a probe is used to apply heat to the tumor. This heat destroys the tumor cells under CT guidance. This method is often used for osteoid osteomas. Another method is cryoablation, which uses extreme cold. This can be easier to monitor on a CT scan than RFA. These techniques are also being explored to help reduce pain in patients with metastatic disease.

History shows that bone tumors have existed for a very long time. The earliest known case was an osteosarcoma found in a foot bone. This was discovered in South Africa in a bone from 1.6 to 1.8 million years ago. Today, medical science continues to study these growths to improve outcomes. In the United States, the average five-year survival rate for bone and joint cancer is 68%. While primary bone tumors are rare, making up about 0.2% of all tumors, research remains vital for patient care.

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