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Artificial organ

life science Maturity 7-9 Next article →

An artificial organ is a human-made device or tissue implanted into a person. These devices interface with living tissue to replace a natural organ or augment its functions. The goal is to help a patient return to a normal life as soon as possible. This replacement does not always involve life support. For example, hip replacements involve artificial bones and joints. To be classified as an artificial organ, a device must not be continuously tethered to a stationary power supply. It also cannot require stationary resources like filters or chemical processing units. A dialysis machine is a vital life support tool, but it is not an artificial organ because it is not self-contained.

Brain-Controlled Prosthetic Arm 2
Brain-Controlled Prosthetic Arm 2

Constructing these organs is an expensive and research-intensive process. They often require years of ongoing maintenance that natural organs do not need. The purposes for these devices vary widely. An artificial heart may provide life support while a patient waits for a transplant. An artificial limb can improve a patient's ability to care for themselves. A cochlear implant can help a person interact socially. Some devices even provide cosmetic restoration after an accident or cancer surgery. Because of the risks, use is almost always preceded by extensive animal experiments. Human testing is often limited to patients facing death or those who have exhausted all other treatments.

Cochlear implant
Cochlear implant

Artificial limbs, or prosthetics, aim to restore function to amputees. Since the use of simple peg legs in ancient times, technology has progressed rapidly. Modern limbs use materials like carbon fiber to be stronger and lighter. This reduces the extra energy a person needs to operate the limb. Some advanced prosthetics integrate directly with the human body. Electrodes can be placed into nervous tissue to allow the body to control the device. The brain can control a prosthetic through a direct implant or by using various muscles.

Bionic Eye
Bionic Eye
Artificial-heart-london
Artificial-heart-london

Neural prostheses substitute motor, sensory, or cognitive functions damaged by disease or injury. Neurostimulators, such as deep brain stimulators, send electrical impulses to the brain. These treat disorders like Parkinson's disease, epilepsy, and treatment-resistant depression. Instead of replacing networks, they often disrupt malfunctioning nerve centers to stop symptoms. In the sensory realm, cochlear implants help those with profound deafness. These devices use external microphones and electronics to send signals to electrodes in the cochlea. These electrodes then stimulate the cochlear nerve. Artificial eyes represent another frontier. Currently, miniature digital cameras can be implanted on the retina or optic nerve. These allow users to recognize brightness, color swatches, and basic geometric shapes.

Artificial Lung
Artificial Lung

Cardiovascular devices address issues with the heart or circulatory system. An artificial heart can bridge the time until a transplant or act as a permanent replacement. Ventricular assist devices are mechanical tools that partially or completely replace a failing heart's function. They do not require the removal of the natural heart. Pacemakers can also be implanted to augment or bypass the natural cardiac pacemaker. Researchers are also studying lab-grown and 3D bioprinted hearts. However, creating blood vessels and cohesive tissues remains a major challenge. Similarly, researchers at MC3 are working on artificial lungs. One method, called Extracorporeal Membrane Oxygenation (ECMO), uses a pump to flow blood over membrane fibers. This allows the blood to exchange oxygen and carbon dioxide, letting the native lungs heal.

Artificial Lung
Artificial Lung

Other specialized artificial organs target specific biological systems. To treat erectile dysfunction, surgeons can replace the corpora cavernosa with manually inflatable penile implants. These use a pump in the groin to fill artificial cylinders from an implanted reservoir. For bladder replacement, doctors may fashion a pouch from intestinal tissue. In 2017, clinical research explored growing bladders using stem cells. In the reproductive system, scientists at Brown University developed artificial ovaries using 3-D petri dish technology. In 2017, an NIH-funded study successfully implanted 3-D printed ovaries into mice. For diabetes, an artificial pancreas can substitute endocrine functions. This can be done via insulin pumps under closed-loop control or through biocompatible sheets of encapsulated beta cells.

Artificial-heart-london
Artificial-heart-london

Finally, nanotechnology is transforming the development of artificial red blood cells (RBC). The first artificial RBC was created by Chang and Poznanski in 1968 to transport oxygen and carbon dioxide. New versions are only one-fiftieth the size of a human RBC. These are made from purified hemoglobin proteins coated in a synthetic polymer. This coating allows the cells to be "immune silent," meaning they can be used by anyone regardless of blood type. The polymer also prevents the hemoglobin from reacting with nitric oxide. This prevents the dangerous constriction of blood vessels. These tiny cells can capture oxygen when blood pH is high and release it when pH is low.

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🖼️ Images & Media (6)
File:Brain-Controlled Prosthetic Arm 2.jpg
Brain-Controlled Prosthetic Arm 2.jpg
File:Hippocampal Prosthesis.jpg
Hippocampal Prosthesis.jpg
File:Cochlear implant.jpg
Cochlear implant.jpg
File:Bionic Eye.jpg
Bionic Eye.jpg
File:Artificial-heart-london.JPG
Artificial-heart-london.JPG
File:Artificial Lung.jpg
Artificial Lung.jpg
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