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Allergen

life science Maturity 11-13 Next article →

An allergen is a substance that is usually harmless to most people. However, it can trigger an allergic reaction in sensitive individuals. This happens when the immune system makes a mistake. It treats the harmless substance like a threat. This response is called a type-I hypersensitivity reaction. In these people, the body produces specific antibodies called immunoglobulin E, or IgE. Most humans only make these antibodies to fight off parasitic infections. For some, the immune system reacts to common things in the air or food instead.

Misc pollen
Misc pollen

When an allergen enters a sensitive person's body, a specific chain of events begins. The immune system creates IgE antibodies to target that substance. These antibodies then travel to mast cells. These cells line parts of the body like the nose, eyes, and lungs. If the allergen enters the body again, the mast cells release chemicals called histamines. These chemicals cause inflammation and irritation. This is why people feel itchy or start sneezing.

House Dust Mite
House Dust Mite

Scientists and groups like the World Health Organization study these substances. They maintain a list of proteins that cause IgE reactions in humans. Many different things can be allergens. Common examples include pollen from trees and grasses. Dust mite waste is another common trigger. Some people are also sensitive to animal dander or mold spores. Even certain metals like nickel can cause reactions through skin contact.

Peanuts, Egg, and Milk (33000737773)
Peanuts, Egg, and Milk (33000737773)

Different countries have different rules for what they call major food allergens. In the United States, the FDA recognizes nine major foods. These include things like peanuts, seafood, and milk. Canada recognizes those same nine plus mustard. The European Union also recognizes other organic grains. Some people have very serious reactions to things like bee stings or penicillin. An extremely serious reaction is called anaphylaxis. This can be treated with sterile epinephrine to stop the body's overreaction.

Peanuts, Egg, and Milk (33000737773)
Peanuts, Egg, and Milk (33000737773)

Allergies are often linked to the world around us. For example, seasonal allergies happen when trees or grasses pollinate. In the spring, trees like oak and maple release pollen. In the summer, grasses like Bermuda pollinate. Some people find that their allergies get worse due to climate change. This is because global warming can increase tree pollen. If both parents have allergies, there is a 66% chance a child will have them too. Knowing your triggers helps you stay healthy.

Misc pollen
Misc pollen
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House Dust Mite.jpg
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Peanuts, Egg, and Milk (33000737773).jpg
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